[HTML][HTML] Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-β peptide degradation
…, P Chandakkar, H Zhao, C d'Abramo… - The FASEB …, 2011 - ncbi.nlm.nih.gov
AMP-activated protein kinase (AMPK) is a metabolic sensor involved in intracellular energy
metabolism through the control of several homeostatic mechanisms, which include …
metabolism through the control of several homeostatic mechanisms, which include …
[HTML][HTML] Tau passive immunotherapy in mutant P301L mice: antibody affinity versus specificity
C d'Abramo, CM Acker, HT Jimenez, P Davies - PloS one, 2013 - journals.plos.org
The use of antibodies to treat neurodegenerative diseases has undergone rapid development
in the past decade. To date, immunotherapeutic approaches to Alzheimer’s disease have …
in the past decade. To date, immunotherapeutic approaches to Alzheimer’s disease have …
[HTML][HTML] CB2 Receptor Deficiency Increases Amyloid Pathology and Alters Tau Processing in a Transgenic Mouse Model of Alzheimer's Disease
J Koppel, V Vingtdeux, P Marambaud, C d'Abramo… - Molecular …, 2014 - Springer
The endocannabinoid CB 2 receptor system has been implicated in the neuropathology of
Alzheimer’s disease (AD). In order to investigate the impact of the CB 2 receptor system on …
Alzheimer’s disease (AD). In order to investigate the impact of the CB 2 receptor system on …
Microarray analysis in Alzheimer's disease and normal aging
R Ricciarelli, C d'Abramo, S Massone, UM Marinari… - IUBMB …, 2004 - Wiley Online Library
The purpose of this study was to investigate gene expression in Alzheimer's disease (AD),
the most common form of senile dementia. We utilized the microarray technology to …
the most common form of senile dementia. We utilized the microarray technology to …
Role of peroxisome proliferator-activated receptor γ in amyloid precursor protein processing and amyloid β-mediated cell death
Recent data indicate that PPARγ (peroxisome proliferator-activated receptor γ) could be
involved in the modulation of the amyloid cascade causing Alzheimer's disease. In the present …
involved in the modulation of the amyloid cascade causing Alzheimer's disease. In the present …
[HTML][HTML] Significance of blood and cerebrospinal fluid biomarkers for Alzheimer's disease: sensitivity, specificity and potential for clinical use
C d'Abramo, L D'adamio, L Giliberto - Journal of Personalized Medicine, 2020 - mdpi.com
Alzheimer’s disease (AD) is the most common type of dementia, affecting more than 5 million
Americans, with steadily increasing mortality and incredible socio-economic burden. Not …
Americans, with steadily increasing mortality and incredible socio-economic burden. Not …
CD36 overexpression in human brain correlates with β-amyloid deposition but not with Alzheimer's disease
R Ricciarelli, C d'Abramo, JM Zingg, L Giliberto… - Free Radical Biology …, 2004 - Elsevier
Scavenger receptors recently have been related to Alzheimer's disease, although it is still
unclear whether they contribute to the pathogenesis of the disease or reflect an inflammatory …
unclear whether they contribute to the pathogenesis of the disease or reflect an inflammatory …
Memory deficits due to familial British dementia BRI2 mutation are caused by loss of BRI2 function rather than amyloidosis
R Tamayev, L Giliberto, W Li, C d'Abramo… - Journal of …, 2010 - Soc Neuroscience
Familial dementias, which include Alzheimer disease (AD), familial British dementia (FBD),
and familial Danish dementia (FDD), are caused by dominantly inherited autosomal …
and familial Danish dementia (FDD), are caused by dominantly inherited autosomal …
[HTML][HTML] Anti-tau conformational scFv MC1 antibody efficiently reduces pathological tau species in adult JNPL3 mice
…, S Ruiz, K Steslow, P Marambaud, C d'Abramo - Acta neuropathologica …, 2018 - Springer
Tau, the main component of the neurofibrillary tangles (NFTs), is an attractive target for
immunotherapy in Alzheimer’s disease (AD) and other tauopathies. MC1/Alz50 are currently the …
immunotherapy in Alzheimer’s disease (AD) and other tauopathies. MC1/Alz50 are currently the …
Sensitive quantitative assays for tau and phospho-tau in transgenic mouse models
…, SK Forest, R Zinkowski, P Davies, C d'Abramo - Neurobiology of …, 2013 - Elsevier
Transgenic mouse models have been an invaluable resource in elucidating the complex
roles of β-amyloid and tau in Alzheimer's disease. Although many laboratories rely on …
roles of β-amyloid and tau in Alzheimer's disease. Although many laboratories rely on …