User profiles for D. P. Holt
Daniel HoltJohns Hopkins University School of Medicine Verified email at jhmi.edu Cited by 14452 |
Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound‐B
…, Y Wang, G Blomqvist, DP Holt… - Annals of Neurology …, 2004 - Wiley Online Library
This report describes the first human study of a novel amyloid‐imaging positron emission
tomography (PET) tracer, termed Pittsburgh Compound‐B (PIB), in 16 patients with diagnosed …
tomography (PET) tracer, termed Pittsburgh Compound‐B (PIB), in 16 patients with diagnosed …
Synthesis and Evaluation of 11C-Labeled 6-Substituted 2-Arylbenzothiazoles as Amyloid Imaging Agents
The synthesis and evaluation of a series of neutral analogues of thioflavin-T (termed BTA's)
with high affinities for aggregated amyloid and a wide range of lipophilicities are reported. …
with high affinities for aggregated amyloid and a wide range of lipophilicities are reported. …
Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-B
A valid quantitative imaging method for the measurement of amyloid deposition in humans
could improve Alzheimer's disease (AD) diagnosis and antiamyloid therapy assessment. Our …
could improve Alzheimer's disease (AD) diagnosis and antiamyloid therapy assessment. Our …
Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain
In vivo assessment of the beta-sheet proteins deposited in amyloid plaques (Aβ peptide) or
neurofibrillary tangles (tau protein) presents a target for the development of biological …
neurofibrillary tangles (tau protein) presents a target for the development of biological …
A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain
The synthesis of a new lipophilic thioflavin-T analogue (2-[4′-(methylamino)phenyl]benzothiazole,
6) with high affinity for amyloid is reported. Intravenous injection of [ 11 C]-labeled 6 …
6) with high affinity for amyloid is reported. Intravenous injection of [ 11 C]-labeled 6 …
Imaging Aβ plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative
The identification of amyloid deposits in living Alzheimer disease (AD) patients is important
for both early diagnosis and for monitoring the efficacy of newly developed anti-amyloid …
for both early diagnosis and for monitoring the efficacy of newly developed anti-amyloid …
Binding of the positron emission tomography tracer Pittsburgh compound-B reflects the amount of amyloid-β in Alzheimer's disease brain but not in transgenic mouse …
…, EE Abrahamson, ML Debnath, DP Holt… - Journal of …, 2005 - Soc Neuroscience
During the development of in vivo amyloid imaging agents, an effort was made to use micro-positron
emission tomography (PET) imaging in the presenilin-1 (PS1)/amyloid precursor …
emission tomography (PET) imaging in the presenilin-1 (PS1)/amyloid precursor …
Longitudinal cognitive decline is associated with fibrillar amyloid-beta measured by [11C]PiB
Objective: To investigate whether longitudinal declines in cognition are associated with higher
fibrillar amyloid-beta (Aβ) deposition in vivo in individuals without dementia. Method: [ 11 …
fibrillar amyloid-beta (Aβ) deposition in vivo in individuals without dementia. Method: [ 11 …
The binding of 2-(4′-methylaminophenyl) benzothiazole to postmortem brain homogenates is dominated by the amyloid component
…, Y Wang, G Huang, ML Debnath, DP Holt… - Journal of …, 2003 - Soc Neuroscience
2-(4′-Methylaminophenyl)benzothiazole (BTA-1) is an uncharged derivative of thioflavin-T
that has high affinity for Aβ fibrils and shows very good brain entry and clearance. In this …
that has high affinity for Aβ fibrils and shows very good brain entry and clearance. In this …
Biodistribution, tumor detection, and radiation dosimetry of 18F-DCFBC, a low-molecular-weight inhibitor of prostate-specific membrane antigen, in patients with …
…, S Senthamizhchelvan, DP Holt… - Journal of Nuclear …, 2012 - Soc Nuclear Med
Prostate-specific membrane antigen (PSMA) is a type II integral membrane protein
expressed on the surface of prostate cancer (PCa) cells, particularly in androgen-independent, …
expressed on the surface of prostate cancer (PCa) cells, particularly in androgen-independent, …