In this review, we argue that at least one insult that causes Alzheimer’s disease (AD) is
disruption of the normal function of the amyloid precursor protein (APP). Familial Alzheimer’s …

… of DL McPhie and RL Neve). The effect of the constitutively active JNK3 is not blocked by a
dominant-negative mutant of PAK3, implying that the action of JNK3 is downstream of PAK3. …

The recent demonstration of K+ channel dysfunction in fibroblasts from Alzheimer disease (AD)
patients and past observations of Ca(2+)-mediated K+ channel modulation during …

Postmortem, genetic, brain imaging, and peripheral cell studies all support decreased
mitochondrial activity as a factor in the manifestation of Bipolar Disorder (BD). Because abnormal …

The molecular basis for the degeneration of neurons and the deposition of amyloid in plaques
and in the cerebrovasculature in Alzheimer’s disease (AD) is incompletely understood. …

Body-wide changes in bioenergetics, ie, energy metabolism, occur in normal aging and
disturbed bioenergetics may be an important contributing mechanism underlying late-onset …

Activation of protein kinase C (PKC) can mimic the biophysical effects of associative learning
on neurons. Furthermore, classical conditioning of the rabbit nictitating membrane (a form …

Apoptotic pathways and DNA synthesis are activated in neurons in the brains of individuals
with Alzheimer disease (AD). However, the signaling mechanisms that mediate these events …

Bipolar disorder (BD) is associated with abnormal circadian rhythms. In treatment responsive
BD patients, lithium (Li) stabilizes mood and reduces suicide risk. Li also affects circadian …

We generated cortical interneurons (cINs) from induced pluripotent stem cells derived from
14 healthy controls and 14 subjects with schizophrenia. Both healthy control cINs and …