On the basis of electrophysiological analysis of Shaker mutants, the Shaker locus of
Drosophila melanogaster has been proposed to encode a structural component of a voltage-…

Potassium currents are crucial for the repolarization of electrically excitable membranes, a
role that makes potassium channels a target for physiological modifications that alter synaptic …

… for fluctuation analysis, ionic currents were static interactions with each other (Papazian et
al., … B) and the Pew Charitable Trusts (to DM P). The costs of publication of this article were …

Voltage-dependent potassium, sodium and calcium ion channels may share a common
mechanism of activation, in which the conserved S4 sequence acts as the primary voltage sensor…

The S4 segment comprises part of the voltage sensor in Shaker K+ channels. We have
used a strategy similar to intragenic suppression, but without a genetic selection, to identify …

… Papazian, Yuh Nung Jan & Lily Y. Jan … Papazian, DM, Schwarz, TL, Tempel, BL, Jan,
YN & Jan, LY Science 237, 749–753 (1987). … Tempel, BL, Papazian, DM, Schwarz, TL …

Potassium channel mutations have been described in episodic neurological diseases 1 . We
report that K + channel mutations cause disease phenotypes with neurodevelopmental and …

The Shaker gene of Drosophila melanogaster encodes a potassium-selective ion channel,
the 'A' channel, or one of its subunits. A single Shaker messenger RNA species suffices to …

Voltage-dependent ion channels respond to changes in the membrane potential by means
of charged voltage sensors intrinsic to the channel protein. Changes in transmembrane …

… Wright, and members of the Papazian laboratory for their comments on the manuscript, and
to … Bezanilla, and DM Papazian. 1994. S4 mutations alter gating currents of Shaker K+ chan…