User profiles for David J. Combs

David J Combs MD PhD

Instructor in Anesthesia, Birgham and Women's Hospital
Verified email at bwh.harvard.edu
Cited by 151

Motor performance in rats exposed to severe forebrain ischemia: effect of fasting and 1, 3-butanediol.

DJ Combs, LG D'Alecy - Stroke, 1987 - Am Heart Assoc
Functional assessment of animals following experimental cerebral ischemia is often difficult
due to the passive nature of many neurologic exams. We attempted to increase the …

Moderate hypothermia reduces postischemic edema development and leukotriene production

RJ Dempsey, DJ Combs, ME Maley, DE Cowen… - …, 1987 - journals.lww.com
: Using the bilateral carotid artery occlusion model of cerebral ischemia in the gerbil, we
studied the effect of moderate hypothermia (30 to 31 [degrees] C) on the postischemic …

Relationship between plasma glucose, brain lactate, and intracellular pH during cerebral ischemia in gerbils.

DJ Combs, RJ Dempsey, M Maley, D Donaldson… - Stroke, 1990 - Am Heart Assoc
The dose-response relation between plasma glucose and brain lactate and the relation of
these parameters to intracellular pH during severe cerebral ischemia have not been well …

Morphometric evaluation of brain infarcts in rats and gerbils

…, BS Solik, RS Frank, PS Lacy, DJ Combs… - Journal of …, 1986 - Elsevier
The Levine rat prepartion, the gerbil stroke model, and appropriate control animals were
used to determine if the 2,3,5-triphenyltetrazolium chloride (TTC) would selectively identify …

Glycolytic inhibition by 2-deoxyglucose reduces hyperglycemia-associated mortality and morbidity in the ischemic rat.

DJ Combs, DS Reuland, DB Martin, GB Zelenock… - Stroke, 1986 - Am Heart Assoc
Numerous laboratories have shown that hyperglycemia increases cerebral ischemic
damage. This presumably results from increased lactate production and accumulation during …

Validation of algorithms to identify adverse perinatal outcomes in the Medicaid Analytic Extract database

…, D Bartels, S Burns, DJ Combs, J Cottral… - … and drug safety, 2020 - Wiley Online Library
Background The Medicaid Analytic eXtract (MAX) is a health care utilization database from
publicly insured individuals that has been used for studies of drug safety in pregnancy. Claims…

Tuning voltage-gated channel activity and cellular excitability with a sphingomyelinase

DJ Combs, HG Shin, Y Xu, Y Ramu, Z Lu - Journal of General …, 2013 - rupress.org
Voltage-gated ion channels generate action potentials in excitable cells and help set the
resting membrane potential in nonexcitable cells like lymphocytes. It has been difficult to …

Extended peptoids: a new class of oligomers based on aromatic building blocks

DJ Combs, RS Lokey - Tetrahedron letters, 2007 - Elsevier
Peptoids (N-substituted polyglycines) represent a class of bioinspired oligomers that have
unique physical and structural properties. Here, we report the construction of ‘extended …

Post-translational regulation and nuclear entry of TIMELESS and PERIOD are affected in new timeless mutant

T Hara, K Koh, DJ Combs, A Sehgal - Journal of Neuroscience, 2011 - Soc Neuroscience
The molecular circadian clock consists of a feedback loop in which canonical clock proteins
negatively regulate transcription of their own genes. Timed nuclear entry of these proteins is …

Difluoromethylornithine decreases postischemic brain edema and blood-brain barrier breakdown

MP Schmitz, DJ Combs, RJ Dempsey - Neurosurgery, 1993 - journals.lww.com
BRAIN POLYAMINES HAVE been associated with posttraumatic vasogenic edema and
blood-brain barrier (BBB) breakdown seen in some models of brain injury. We hypothesized that …