TASK channels are acid-sensitive and anesthetic-activated members of the family of two-pore-domain
potassium channels. We have made the surprising discovery that the genetic …

The activity of histaminergic neurons in the tuberomammillary nucleus (TMN) of the hypothalamus
correlates with an animal's behavioral state and maintains arousal. We examined how …

Gene therapies have the potential to cure rare conditions that often have no current efficacious
treatments with a one-time treatment episode, relieving substantial unmet need and …

EVIDENCE THAT RENAL PROSTAGLANDIN AND THROMBOXANE PRODUCTION... :
Transplantation EVIDENCE THAT RENAL PROSTAGLANDIN AND THROMBOXANE …

Contrary to popular belief, medieval municipal populations and governments took pains to
improve their urban environments. Their efforts frequently focused on controlling the impact of …

Since its approval in 1997 by the FDA, rituximab has been approved for use in certain B‐cell
lymphomas and treatment‐resistant rheumatoid arthritis. Over the past 10 years, many case …

Five percent of patients with cutaneous squamous cell carcinoma develop locally advanced
or metastatic disease that is not amenable to definitive surgical or radiation therapy. …

Current use of microbes for metabolic engineering suffers from loss of metabolic output due
to natural selection. Rather than combat the evolution of bacterial populations, we chose to …

Background: Extramammary Paget’s disease (EMPD) is a rare neoplasm that affects
apocrine gland-bearing skin. Patients usually present with a long-standing, unilateral, ill-defined, …

Spiradenomas are rare skin adnexal tumors, usually benign, appearing in early adulthood.
The etiology of this tumor is still debated. The tumor suppressor gene CYLD , responsible for …