Both the sec6/8 complex and septin filaments have been implicated in directing vesicles
and proteins to sites of active membrane addition in yeast. The rat brain sec6/8 complex …

The molecules that specify domains on the neuronal plasma membrane for the delivery and
accumulation of vesicles during neurite outgrowth and synapse formation are unknown. We …

The trans-Golgi network (TGN) plays a pivotal role in directing proteins in the secretory
pathway to the appropriate cellular destination. VAMP4, a recently discovered member of the …

The delivery of secretory vesicles to appropriate docking and fusion sites on the plasma
membrane is crucial for many cellular functions, including formation of synapses, exocytosis of …

Neurons are polarized cells, the activity of which relies on the morphological and functional
differences between their axonal and somatodendritic domains. One mechanism for …

Syntaxin 1 is a SNARE protein that plays a central role in synaptic vesicle (SV) exocytosis.
We generated an antibody that specifically recognizes a casein kinase II-mediated …

Stanford, California 94305 cific trafficking. However, the predominant localization of the plus
end–directed motor protein (KIF21B) to the soma and dendrites appears inconsistent with …

The dynamic modulation of protein function by phosphorylation plays an important role in
regulating synaptic plasticity. Several proteins involved in synaptic transmission have been …

Purpose: To investigate the effectiveness of a high-affinity human monoclonal antibody Fab
fragment to Staphylococcus aureus alpha-toxin (LTM14 Fab) as therapy for S. aureus …

Protein kinases and phosphatases play an important role in modulating synaptic transmission.
The synaptic protein rabphilin associates with synaptic vesicles through the small …