The epithelial canine and porcine kidney cell lines MDCK, MDCKII and LLC-PK1, respectively
are employed to establish recombinant models of drug transport. Endogenous drug …

Introduction Guillain-Barré syndrome (GBS) is an autoimmune disease that results in acute
paralysis through inflammatory attack on peripheral nerves, and currently has limited, non-…

In Guillain-Barré syndrome (GBS), both axonal and demyelinating variants can be mediated
by complement-fixing anti–GM1 ganglioside autoantibodies that target peripheral nerve …

Vinca alkaloids are important chemotherapeutic agents, and their pharmacokinetic properties
display significant interindividual variations, possibly due to CYP3A4-mediated metabolism…

Gangliosides are widely expressed sialylated glycosphingolipids with multifunctional properties
in different cell types and organs. In the nervous system, they are highly enriched in both …

Sulfatides and gangliosides are raft-associated glycolipids essential for maintaining myelinated
nerve integrity. Mice deficient in sulfatide (cerebroside sulfotransferase knock-out, CST −/…

In mouse models of acute motor axonal neuropathy, anti‐ganglioside antibodies (AGAbs)
bind to motor axons, notably the distal nerve, and activate the complement cascade. While …

We have recently shown that drug conjugation catalysed by UDP-glucuronosyltransferases (UGTs)
functions as an intrinsic mechanism of resistance to the topoisomerase I inhibitors 7-…

The major determinant of poor outcome in Guillain‐Barré syndrome (GBS) is axonal
degeneration. Pathways leading to primary axonal injury in the motor axonal variant are well …

The involvement of the complement pathway in Guillain–Barré syndrome pathogenesis has
been demonstrated in both patient biosamples and animal models. One proposed …