[HTML][HTML] Selective α-synuclein knockdown in monoamine neurons by intranasal oligonucleotide delivery: potential therapy for Parkinson's disease
D Alarcón-Arís, A Recasens, M Galofré… - Molecular Therapy, 2018 - cell.com
Progressive neuronal death in brainstem nuclei and widespread accumulation of α-synuclein
are neuropathological hallmarks of Parkinson's disease (PD). Reduction of α-synuclein …
are neuropathological hallmarks of Parkinson's disease (PD). Reduction of α-synuclein …
[HTML][HTML] Human α-synuclein overexpression in mouse serotonin neurons triggers a depressive-like phenotype. Rescue by oligonucleotide therapy
L Miquel-Rio, D Alarcón-Arís, M Torres-López… - Translational …, 2022 - nature.com
Anxiety and depression affect 35–50% of patients with Parkinson’s disease (PD), often
precede the onset of motor symptoms, and have a negative impact on their quality of life. …
precede the onset of motor symptoms, and have a negative impact on their quality of life. …
[HTML][HTML] Anti-α-synuclein ASO delivered to monoamine neurons prevents α-synuclein accumulation in a Parkinson's disease-like mouse model and in monkeys
D Alarcón-Arís, R Pavia-Collado, L Miquel-Rio… - …, 2020 - thelancet.com
Background Progressive neuronal death in monoaminergic nuclei and widespread accumulation
of α-synuclein are neuropathological hallmarks of Parkinson's disease (PD). Given that …
of α-synuclein are neuropathological hallmarks of Parkinson's disease (PD). Given that …
[HTML][HTML] Intracerebral Administration of a ligand-ASO conjugate selectively reduces α-synuclein accumulation in monoamine neurons of double mutant human A30P …
…, L Miquel-Rio, D Alarcón-Aris… - International journal of …, 2021 - mdpi.com
α-Synuclein (α-Syn) protein is involved in the pathogenesis of Parkinson’s disease (PD). Point
mutations and multiplications of the α-Syn, which encodes the SNCA gene, are correlated …
mutations and multiplications of the α-Syn, which encodes the SNCA gene, are correlated …
[HTML][HTML] Up and down γ-synuclein transcription in dopamine neurons translates into changes in dopamine neurotransmission and behavioral performance in mice
…, R Rodríguez-Aller, D Alarcón-Arís… - International journal of …, 2022 - mdpi.com
The synuclein family consists of α-, β-, and γ-Synuclein (α-Syn, β-Syn, and γ-Syn) expressed
in the neurons and concentrated in synaptic terminals. While α-Syn is at the center of …
in the neurons and concentrated in synaptic terminals. While α-Syn is at the center of …
Synaptic regulator α-synuclein in dopaminergic fibers is essentially required for the maintenance of subependymal neural stem cells
…, J Villadiego, D Alarcón-Arís… - Journal of …, 2018 - Soc Neuroscience
Synaptic protein α-synuclein (α-SYN) modulates neurotransmission in a complex and poorly
understood manner and aggregates in the cytoplasm of degenerating neurons in Parkinson…
understood manner and aggregates in the cytoplasm of degenerating neurons in Parkinson…
α-Synucleinopathy in serotonin pathways evokes a depressive phenotype in mice―Reversal by conjugated antisense therapy
L Miquel-Rio, D Alarcón-Arís, R Pavia-Collado… - 2020 - digital.csic.es
… ORCID; Alarcón-Arís, Diana …
Endoplasmic reticulum stress in mouse serotonin and dopamine neurons increases¿-synuclein oligomerization, resulting in motor deficits and depressive phenotype
L Miquel-Rio, V Coppola-Segovia, D Alarcón-Arís… - 2020 - digital.csic.es
… ORCID; Alarcón-Arís, Diana …
Proteína alfa-sinucleína y modulación de los sistemas monoaminérgicos. Desde la función fisiológica a diana terapéutica utilizando ácidos nucleicos de interferencia
D Alarcón-Arís - 2019 - digital.csic.es
La proteína o-Slnucleína (o-Syn) se expresa de forma abundante en el cerebro, representado
aproximadamente el 1% del total de la proteína citosólica, localizada principalmente en …
aproximadamente el 1% del total de la proteína citosólica, localizada principalmente en …
Human α-synuclein overexpression in mouse raphe nuclei induces Parkinson's disease pathology. Reversal by conjugated antisense therapy
D Alarcón-Arís, R Pavia-Collado, A Ferrés-Coy… - 2019 - digital.csic.es
Human α-synuclein overexpression in mouse raphe nuclei induces Parkinson's disease
pathology. Reversal by conjugated antisense therapy | DIGITAL.CSIC Skip navigation Logo …
pathology. Reversal by conjugated antisense therapy | DIGITAL.CSIC Skip navigation Logo …