Recent studies have implicated epigenetic remodeling in brain reward regions following
psychostimulant or stress exposure. It has only recently become possible to target a given type …

Chronic social defeat stress regulates the expression of Fosb in the nucleus accumbens (NAc)
to promote the cell-type-specific accumulation of ΔFosB in the two medium spiny neuron (…

Growth arrest-specific protein 6 (GAS6) is a soluble agonist of the TYRO3, AXL, MERTK (TAM)
family of receptor tyrosine kinases identified to have anti-inflammatory, neuroprotective, …

… -induced changes in Auts2 and Caln1 expression were not observed in whole NAc extracts
(10), we demonstrate that increased Auts2 and Caln1 transcription occurs selectively in D 2 -…

Many analgesics inadequately address the psychiatric comorbidities of chronic and persistent
pain, but there is no standard preclinical model of pain-altered behavior to support the …

… Dominika Burek b , Christian A. Hübner a , Jean-Antoine Girault c d , Olivia Engmann a b
c d … 3D), while only having a very mild or no effect in the forced swim test and novelty …

Pain puts patients at risk for developing psychiatric conditions such as anxiety and depression.
Preclinical mouse models of pain-induced affective behavior vary widely in methodology …

Background Exposure to drugs of abuse alters the epigenetic landscape of the brain’s reward
regions such as the nucleus accumbens (NAc). We investigated how a combination of …

… Thank you to my sister, Olivia Burek, for your patience and grace. I am so happy we will
be … Dziękuję mama i tata, my parents Elwira and Paul Burek, for taking the immense risk of …