User profiles for Dong Chuan Wu
Dong Chuan WuChina Medical University, Taiwan Verified email at mail.cmu.edu.tw Cited by 3101 |
NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo
Well-documented experimental evidence from both in vitro and in vivo models of stroke
strongly supports the critical involvement of NMDA receptor-mediated excitotoxicity in neuronal …
strongly supports the critical involvement of NMDA receptor-mediated excitotoxicity in neuronal …
PKMζ maintains memories by regulating GluR2-dependent AMPA receptor trafficking
The maintenance of long-term memory in hippocampus, neocortex and amygdala requires
the persistent action of the atypical protein kinase C isoform, protein kinase Mζ (PKMζ). We …
the persistent action of the atypical protein kinase C isoform, protein kinase Mζ (PKMζ). We …
[PDF][PDF] A critical role for myosin IIb in dendritic spine morphology and synaptic function
Dendritic spines show rapid motility and plastic morphology, which may mediate information
storage in the brain. It is presently believed that polymerization/depolymerization of actin is …
storage in the brain. It is presently believed that polymerization/depolymerization of actin is …
NMDA GluN2A and GluN2B receptors play separate roles in the induction of LTP and LTD in the amygdala and in the acquisition and extinction of conditioned fear
Synaptic plasticity mediated by NMDA glutamate receptors is thought to be a primary
mechanism underlying the formation of new memories. Activation of GluN2A NMDA receptor …
mechanism underlying the formation of new memories. Activation of GluN2A NMDA receptor …
[HTML][HTML] LTP inhibits LTD in the hippocampus via regulation of GSK3β
Glycogen synthase kinase-3 (GSK3) has been implicated in major neurological disorders,
but its role in normal neuronal function is largely unknown. Here we show that GSK3β …
but its role in normal neuronal function is largely unknown. Here we show that GSK3β …
Regenerative glutamate release by presynaptic NMDA receptors contributes to spreading depression
Spreading depression (SD) is a slowly propagating neuronal depolarization that underlies
certain neurologic conditions. The wave-like pattern of its propagation suggests that SD …
certain neurologic conditions. The wave-like pattern of its propagation suggests that SD …
Role of AMPA receptor trafficking in NMDA receptor‐dependent synaptic plasticity in the rat lateral amygdala
SY Yu, DC Wu, L Liu, Y Ge… - Journal of …, 2008 - Wiley Online Library
Stimulated exocytosis and endocytosis of post‐synaptic α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic
acid subtype of glutamate receptors (AMPARs) have been proposed as …
acid subtype of glutamate receptors (AMPARs) have been proposed as …
[HTML][HTML] Astrocytic regulation of glutamate transmission in schizophrenia
YY Mei, DC Wu, N Zhou - Frontiers in psychiatry, 2018 - frontiersin.org
According to the glutamate hypothesis of schizophrenia, the abnormality of glutamate
transmission induced by hypofunction of NMDA receptors (NMDARs) is causally associated with …
transmission induced by hypofunction of NMDA receptors (NMDARs) is causally associated with …
[HTML][HTML] Glutamate and GABAA receptor crosstalk mediates homeostatic regulation of neuronal excitation in the mammalian brain
…, L Zhang, L Liu, J Lu, N Zhou, D Chuan Wu… - … and Targeted Therapy, 2022 - nature.com
Maintaining a proper balance between the glutamate receptor-mediated neuronal excitation
and the A type of GABA receptor (GABA A R) mediated inhibition is essential for brain …
and the A type of GABA receptor (GABA A R) mediated inhibition is essential for brain …
[HTML][HTML] Protective Effects of the Polyphenol Sesamin on Allergen-Induced TH2 Responses and Airway Inflammation in Mice
Allergic asthma is a lifelong airway condition that affects people of all ages. In recent decades,
asthma prevalence continues to increase globally, with an estimated number of 250,000 …
asthma prevalence continues to increase globally, with an estimated number of 250,000 …