[HTML][HTML] Activation of phospholipase C isozymes by G protein beta gamma subunits.
D Park, DY Jhon, CW Lee, KH Lee, SG Rhee - Journal of Biological …, 1993 - Elsevier
The beta gamma subunits of guanine nucleotide-binding proteins (G proteins) have been
shown to activate unidentified phospholipase C (PLC) isozymes (Camps, M., Hou, C., …
shown to activate unidentified phospholipase C (PLC) isozymes (Camps, M., Hou, C., …
[HTML][HTML] Members of the Gq alpha subunit gene family activate phospholipase C beta isozymes.
CH Lee, D Park, D Wu, SG Rhee, MI Simon - Journal of Biological …, 1992 - Elsevier
The relative specificities of members of the G alpha q family of GTP-binding proteins were
tested for their ability to activate different phosphoinositide-specific phospholipase C (PI-PLC) …
tested for their ability to activate different phosphoinositide-specific phospholipase C (PI-PLC) …
Sequential Activation of Phosphatidylinositol 3-Kinase, βPix, Rac1, and Nox1 in Growth Factor-Induced Production of H2O2
HS Park, SH Lee, D Park, JS Lee, SH Ryu… - … and cellular biology, 2004 - Taylor & Francis
The generation of reactive oxygen species (ROS) in cells stimulated with growth factors
requires the activation of phosphatidylinositol 3-kinase (PI3K) and the Rac protein. We report …
requires the activation of phosphatidylinositol 3-kinase (PI3K) and the Rac protein. We report …
[HTML][HTML] The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the βPIX guanine nucleotide exchange factor for Rac1 …
E Park, M Na, J Choi, S Kim, JR Lee, J Yoon… - Journal of Biological …, 2003 - ASBMB
The Shank/ProSAP family of multidomain proteins is known to play an important role in
organizing synaptic multiprotein complexes. Here we report a novel interaction between Shank …
organizing synaptic multiprotein complexes. Here we report a novel interaction between Shank …
[HTML][HTML] The role of carboxyl-terminal basic amino acids in Gqα-dependent activation, particulate association, and nuclear localization of phospholipase C-β1
CG Kim, D Park, SG Rhee - Journal of Biological Chemistry, 1996 - ASBMB
The phospholipase C (PLC)-β isozymes differ from the PLC-γ and PLC-γ isozymes in that
they possess a long COOH-terminal sequence downstream of their catalytic domain, are …
they possess a long COOH-terminal sequence downstream of their catalytic domain, are …
[HTML][HTML] Cloning, sequencing, purification, and Gq-dependent activation of phospholipase C-beta 3.
DY Jhon, HH Lee, D Park, CW Lee, KH Lee… - Journal of Biological …, 1993 - Elsevier
Six mammalian phospholipase C isozymes (PLC-beta 1, PLC-beta 2, PLC-gamma 1, PLC-gamma
2, PLC-delta 1, and PLC-delta 2) have been identified at both protein and DNA levels. …
2, PLC-delta 1, and PLC-delta 2) have been identified at both protein and DNA levels. …
FAK potentiates Rac1 activation and localization to matrix adhesion sites: a role for βPIX
F Chang, CA Lemmon, D Park… - Molecular biology of the …, 2007 - Am Soc Cell Biol
FAK, a cytoplasmic protein tyrosine kinase, is activated and localized to focal adhesions
upon cell attachment to extracellular matrix. FAK null cells spread poorly and exhibit altered …
upon cell attachment to extracellular matrix. FAK null cells spread poorly and exhibit altered …
[HTML][HTML] Phosphorylation of p85 βPIX, a Rac/Cdc42-specific guanine nucleotide exchange factor, via the Ras/ERK/PAK2 pathway is required for basic fibroblast …
…, NK Soung, YG Kim, CI Cha, SR Kim, D Park… - Journal of Biological …, 2002 - ASBMB
Guanine nucleotide exchange factors (GEFs) have been implicated in growth factor-induced
neuronal differentiation through the activation of small GTPases. Although phosphorylation …
neuronal differentiation through the activation of small GTPases. Although phosphorylation …
Regulation of phospholipase C-beta 4 by ribonucleotides and the alpha subunit of Gq.
CW Lee, KH Lee, SB Lee, D Park, SG Rhee - Journal of Biological …, 1994 - ASBMB
The fourth member of mammalian beta-type phospholipase C isozymes, PLC-beta 4, was
recently purified from bovine retina, and the corresponding cDNA was cloned from rat brain …
recently purified from bovine retina, and the corresponding cDNA was cloned from rat brain …
Cloning and chromosomal mapping of a gene isolated from thymic stromal cells encoding a new mouse type II membrane serine protease, epithin, containing four …
MG Kim, C Chen, MS Lyu, EG Cho, D Park, C Kozak… - Immunogenetics, 1999 - Springer
We cloned and sequenced a mouse gene encoding a new type of membrane bound serine
protease (epithin) containing a multidomain structure. The initial cDNA clone was found …
protease (epithin) containing a multidomain structure. The initial cDNA clone was found …