Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease
C Zuccato, A Ciammola, D Rigamonti, BR Leavitt… - Science, 2001 - science.org
Huntingtin is a 350-kilodalton protein of unknown function that is mutated in Huntington's
disease (HD), a neurodegenerative disorder. The mutant protein is presumed to acquire a toxic …
disease (HD), a neurodegenerative disorder. The mutant protein is presumed to acquire a toxic …
Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes
Huntingtin protein is mutated in Huntington disease 1 . We previously reported that wild-type
but not mutant huntingtin stimulates transcription of the gene encoding brain-derived …
but not mutant huntingtin stimulates transcription of the gene encoding brain-derived …
Dominant phenotypes produced by the HD mutation in STHdhQ111 striatal cells
F Trettel, D Rigamonti, P Hilditch-Maguire… - Human molecular …, 2000 - academic.oup.com
Lengthening a glutamine tract in huntingtin confers a dominant attribute that initiates
degeneration of striatal neurons in Huntington’s disease (HD). To identify pathways that are …
degeneration of striatal neurons in Huntington’s disease (HD). To identify pathways that are …
Gene therapy of experimental brain tumors using neural progenitor cells
…, B Pollo, L Magrassi, MG Bruzzone, D Rigamonti… - Nature medicine, 2000 - nature.com
Glioblastomas, the most frequent and malignant of primary brain tumors, have a very poor
prognosis 1. Gene therapy of glioblastomas is limited by the short survival of viral vectors and …
prognosis 1. Gene therapy of glioblastomas is limited by the short survival of viral vectors and …
Wild-type huntingtin protects from apoptosis upstream of caspase-3
D Rigamonti, JH Bauer, C De-Fraja, L Conti… - Journal of …, 2000 - Soc Neuroscience
Expansion of a polyglutamine sequence in the N terminus of huntingtin is the gain-of-function
event that causes Huntington's disease. This mutation affects primarily the medium-size …
event that causes Huntington's disease. This mutation affects primarily the medium-size …
Loss of normal huntingtin function: new developments in Huntington's disease research
E Cattaneo, D Rigamonti, D Goffredo, C Zuccato… - Trends in …, 2001 - cell.com
Huntington's disease is characterized by a loss of brain striatal neurons that occurs as a
consequence of an expansion of a CAG repeat in the huntingtin protein. The resulting extended …
consequence of an expansion of a CAG repeat in the huntingtin protein. The resulting extended …
Dysfunction of the cholesterol biosynthetic pathway in Huntington's disease
M Valenza, D Rigamonti, D Goffredo… - Journal of …, 2005 - Soc Neuroscience
The expansion of a polyglutamine tract in the ubiquitously expressed huntingtin protein causes
Huntington's disease (HD), a dominantly inherited neurodegenerative disease. We show …
Huntington's disease (HD), a dominantly inherited neurodegenerative disease. We show …
Early transcriptional profiles in huntingtin-inducible striatal cells by microarray analyses
Gene expression studies conducted with mouse models of Huntington's disease (HD) have
revealed profound modifications in gene transcription. However, the complexity of in vivo …
revealed profound modifications in gene transcription. However, the complexity of in vivo …
[HTML][HTML] Huntingtin's neuroprotective activity occurs via inhibition of procaspase-9 processing
D Rigamonti, S Sipione, D Goffredo, C Zuccato… - Journal of Biological …, 2001 - ASBMB
Huntington's Disease is an inherited neurodegenerative disease that affects the medium
spiny neurons in the striatum. The disease is caused by the expansion of a polyglutamine …
spiny neurons in the striatum. The disease is caused by the expansion of a polyglutamine …
Progressive loss of BDNF in a mouse model of Huntington's disease and rescue by BDNF delivery
…, D Liber, C Ramos, A Tarditi, D Rigamonti… - Pharmacological …, 2005 - Elsevier
Huntingtin is a protein of 348kDa that is mutated in Huntington's disease (HD), a dominantly
inherited neurodegenerative disorder. Previous data have led us to propose that aspects of …
inherited neurodegenerative disorder. Previous data have led us to propose that aspects of …