Serotonin is a major component of the inflammatory chemical milieu and contributes to the
pain of tissue injury via an action on multiple receptor subtypes. Here we studied mice after …

1 Full length clones of the human 5‐HT 2B receptor were isolated from human liver, kidney
and pancreas. The cloned human 5‐HT 2B receptors had a high degree of homology (∼80%…

Alpha-2 adrenergic receptors (α 2 AR) mediate incorporation of guanosine 5′-O-(γ-thio)triphosphate
([ 35 S]GTPγS) into isolated membranes via receptor-catalyzed exchange of [ 35 S]…

Currently available treatments for schizophrenia have limited efficacy and are generally poorly
tolerated. However, among these antipsychotic agents, clozapine stands apart in having …

Several series of 2V-(quinuclidin-3-yl) aryl and heteroaryl-fused pyridones were
synthesized and evaluated for 5-HT3 receptor affinity. In the heteroaryl series, 2-(quinuclidin-3-yl) …

Efforts to define precisely the role of 5‐HT 2B receptors in normal and disease processes
have been hindered by the absence of selective antagonists. To address this deficiency, we …

A cDNA clone (designated as GP2‐7) encoding a novel 5‐hydroxytryptamine (5‐HT)
receptor was isolated from a guinea pig hippocampal library. The receptor shares amino acid …

Norepinephrine (NE) contracts smooth muscle cells within the human lower urinary tract (LUT)
(bladder neck, prostate, and urethra). Receptor distribution and pharmacological …

1 Inhibitory modulation of sympathetic nerve function may have a favourable impact on the
progression of congestive heart failure. Nepicastat is a novel inhibitor of dopamine‐β‐…

Direct targeting of alpha-synuclein (ASYN) has emerged as a disease-modifying strategy for
Parkinson’s disease and other synucleinopathies which is being approached using both …