User profiles for Edmund Talley

Edmund M Talley

National Institutes of Health
Verified email at nih.gov
Cited by 9881

[PDF][PDF] Optimizing semantic coherence in topic models

D Mimno, H Wallach, E Talley… - Proceedings of the …, 2011 - aclanthology.org
Latent variable models have the potential to add value to large document collections by
discovering interpretable, low-dimensional subspaces. In order for people to use such models, …

Differential distribution of three members of a gene family encoding low voltage-activated (T-type) calcium channels

EM Talley, LL Cribbs, JH Lee, A Daud… - Journal of …, 1999 - Soc Neuroscience
Low voltage-activated (T-type) calcium currents are observed in many central and
peripheral neurons and display distinct physiological and functional properties. Using in situ …

CNS distribution of members of the two-pore-domain (KCNK) potassium channel family

EM Talley, G Solórzano, Q Lei, D Kim… - Journal of …, 2001 - Soc Neuroscience
Two-pore-domain potassium (K + ) channels are substrates for resting K + currents in
neurons. They are major targets for endogenous modulators, as well as for clinically important …

[PDF][PDF] TASK-1, a two–pore domain K+ channel, is modulated by multiple neurotransmitters in motoneurons

EM Talley, Q Lei, JE Sirois, DA Bayliss - Neuron, 2000 - cell.com
Inhibition of "leak" potassium (K + ) channels is a widespread CNS mechanism by which
transmitters induce slow excitation. We show that TASK-1, a two pore domain K + channel, …

The TASK-1 two-pore domain K+ channel is a molecular substrate for neuronal effects of inhalation anesthetics

JE Sirois, Q Lei, EM Talley, C Lynch… - Journal of …, 2000 - Soc Neuroscience
Despite widespread use of volatile general anesthetics for well over a century, the mechanisms
by which they alter specific CNS functions remain unclear. Here, we present evidence …

Evaluating topic models for digital libraries

D Newman, Y Noh, E Talley, S Karimi… - Proceedings of the 10th …, 2010 - dl.acm.org
Topic models could have a huge impact on improving the ways users find and discover
content in digital libraries and search interfaces through their ability to automatically learn and …

Motoneurons express heteromeric TWIK-related acid-sensitive K+ (TASK) channels containing TASK-1 (KCNK3) and TASK-3 (KCNK9) subunits

AP Berg, EM Talley, JP Manger… - Journal of …, 2004 - Soc Neuroscience
Background potassium currents carried by the KCNK family of two-pore-domain K + channels
are important determinants of resting membrane potential and cellular excitability. TWIK-…

Development of glycinergic synaptic transmission to rat brain stem motoneurons

JH Singer, EM Talley, DA Bayliss… - Journal of …, 1998 - journals.physiology.org
Singer, Joshua H., Edmund M. Talley, Douglas A. Bayliss, and Albert J. Berger. Development
of glycinergic synaptic transmission to rat brain stem motoneurons. J. Neurophysiol. 80: …

Distribution of α2C‐adrenergic receptor‐like immunoreactivity in the rat central nervous system

DL Rosin, EM Talley, A Lee… - Journal of …, 1996 - Wiley Online Library
The distribution of α 2C ‐adrenergic receptors (ARs) in rat brain and spinal cord was examined
immunohistochemically by using an affinity purified polyclonal antibody. The antibody …

Distribution of α2A‐adrenergic receptor‐like immunoreactivity in the rat central nervous system

EM Talley, DL Rosin, A Lee… - Journal of …, 1996 - Wiley Online Library
In this study, we analyzed immunohistochemically the distribution of the A subtype of α 2 ‐adrenergic
receptor (α 2A ‐AR) in the rat central nervous system using light level …