User profiles for Edmund Talley
Edmund M TalleyNational Institutes of Health Verified email at nih.gov Cited by 9881 |
[PDF][PDF] Optimizing semantic coherence in topic models
Latent variable models have the potential to add value to large document collections by
discovering interpretable, low-dimensional subspaces. In order for people to use such models, …
discovering interpretable, low-dimensional subspaces. In order for people to use such models, …
Differential distribution of three members of a gene family encoding low voltage-activated (T-type) calcium channels
EM Talley, LL Cribbs, JH Lee, A Daud… - Journal of …, 1999 - Soc Neuroscience
Low voltage-activated (T-type) calcium currents are observed in many central and
peripheral neurons and display distinct physiological and functional properties. Using in situ …
peripheral neurons and display distinct physiological and functional properties. Using in situ …
CNS distribution of members of the two-pore-domain (KCNK) potassium channel family
Two-pore-domain potassium (K + ) channels are substrates for resting K + currents in
neurons. They are major targets for endogenous modulators, as well as for clinically important …
neurons. They are major targets for endogenous modulators, as well as for clinically important …
[PDF][PDF] TASK-1, a two–pore domain K+ channel, is modulated by multiple neurotransmitters in motoneurons
EM Talley, Q Lei, JE Sirois, DA Bayliss - Neuron, 2000 - cell.com
Inhibition of "leak" potassium (K + ) channels is a widespread CNS mechanism by which
transmitters induce slow excitation. We show that TASK-1, a two pore domain K + channel, …
transmitters induce slow excitation. We show that TASK-1, a two pore domain K + channel, …
The TASK-1 two-pore domain K+ channel is a molecular substrate for neuronal effects of inhalation anesthetics
JE Sirois, Q Lei, EM Talley, C Lynch… - Journal of …, 2000 - Soc Neuroscience
Despite widespread use of volatile general anesthetics for well over a century, the mechanisms
by which they alter specific CNS functions remain unclear. Here, we present evidence …
by which they alter specific CNS functions remain unclear. Here, we present evidence …
Evaluating topic models for digital libraries
Topic models could have a huge impact on improving the ways users find and discover
content in digital libraries and search interfaces through their ability to automatically learn and …
content in digital libraries and search interfaces through their ability to automatically learn and …
Motoneurons express heteromeric TWIK-related acid-sensitive K+ (TASK) channels containing TASK-1 (KCNK3) and TASK-3 (KCNK9) subunits
AP Berg, EM Talley, JP Manger… - Journal of …, 2004 - Soc Neuroscience
Background potassium currents carried by the KCNK family of two-pore-domain K + channels
are important determinants of resting membrane potential and cellular excitability. TWIK-…
are important determinants of resting membrane potential and cellular excitability. TWIK-…
Development of glycinergic synaptic transmission to rat brain stem motoneurons
Singer, Joshua H., Edmund M. Talley, Douglas A. Bayliss, and Albert J. Berger. Development
of glycinergic synaptic transmission to rat brain stem motoneurons. J. Neurophysiol. 80: …
of glycinergic synaptic transmission to rat brain stem motoneurons. J. Neurophysiol. 80: …
Distribution of α2C‐adrenergic receptor‐like immunoreactivity in the rat central nervous system
The distribution of α 2C ‐adrenergic receptors (ARs) in rat brain and spinal cord was examined
immunohistochemically by using an affinity purified polyclonal antibody. The antibody …
immunohistochemically by using an affinity purified polyclonal antibody. The antibody …
Distribution of α2A‐adrenergic receptor‐like immunoreactivity in the rat central nervous system
In this study, we analyzed immunohistochemically the distribution of the A subtype of α 2 ‐adrenergic
receptor (α 2A ‐AR) in the rat central nervous system using light level …
receptor (α 2A ‐AR) in the rat central nervous system using light level …