The transient receptor potential ankyrin subtype 1 protein (TRPA1) is a nonselective cation
channel permeable to Ca 2+ , Na + , and K + . TRPA1 is a promiscuous chemical nocisensor …

The endogenous cannabinoid receptor agonist anandamide 1 is a powerful vasodilator of
isolated vascular preparations 2 , 3 , 4 , but its mechanism of action is unclear. Here we show …

Wasabi, horseradish and mustard owe their pungency to isothiocyanate compounds. Topical
application of mustard oil (allyl isothiocyanate) to the skin activates underlying sensory …

Garlic belongs to the Allium family of plants that produce organosulfur compounds, such as
allicin and diallyl disulfide (DADS), which account for their pungency and spicy aroma. Many …

Acetaminophen (paracetamol) is a popular domestic analgesic and antipyretic agent with a
weak anti-inflammatory action and a low incidence of adverse effects as compared with …

TRPA1 is a unique sensor of noxious stimuli and, hence, a potential drug target for analgesics.
Here we show that the antinociceptive effects of spinal and systemic administration of …

Nitroxyl (HNO) is a redox sibling of nitric oxide (NO) that targets distinct signalling pathways
with pharmacological endpoints of high significance in the treatment of heart failure. …

OBJECTIVES: To investigate the distribution of the transient receptor potential (TRP) A1 ion
channel in the rat urinary bladder, and to study the effects of hydrogen sulfide (H 2 S) and …

The possibility that the anandamide transport inhibitor N-(4-hydroxyphenyl)-5,8,11,14-eicosatetraenamide
(AM404), structurally similar to the vanilloid receptor agonists anandamide …

Background Acetaminophen, the major active metabolite of acetanilide in man, has become
one of the most popular over-the-counter analgesic and antipyretic agents, consumed by …