Capsaicin facilitates excitatory but not inhibitory synaptic transmission in substantia gelatinosa of the rat spinal cord

K Yang, E Kumamoto, H Furue, M Yoshimura - Neuroscience letters, 1998 - Elsevier
Actions of capsaicin were examined on synaptic transmissions in the substantia gelatinosa (SG)
of adult rat spinal cord slices using the whole-cell patch-recording technique. Bath-…

Activation of TRPA1 channel facilitates excitatory synaptic transmission in substantia gelatinosa neurons of the adult rat spinal cord

…, T Fujita, Y Kuroda, E Kumamoto - Journal of …, 2007 - Soc Neuroscience
TRPA1 is expressed in primary sensory neurons and hair cells, and it is proposed to be
activated by cold stimuli, mechanical stimuli, or pungent ingredients. However, its role in …

α2Adrenoceptor–mediated Presynaptic Inhibition of Primary Afferent Glutamatergic Transmission in Rat Substantia Gelatinosa Neurons

Y Kawasaki, E Kumamoto, H Furue… - The Journal of the …, 2003 - pubs.asahq.org
Background Although intrathecal administration of norepinephrine is known to produce
analgesia, cellular mechanisms for this action have not yet been fully understood. Methods The …

High concentrations of dexmedetomidine inhibit compound action potentials in frog sciatic nerves without α2 adrenoceptor activation

…, T Fujita, M Nakashima, E Kumamoto - British journal of …, 2010 - Wiley Online Library
BACKGROUND AND PURPOSE Dexmedetomidine, an α 2 ‐adrenoceptor agonist, exhibits
anti‐nociceptive actions at the spinal cord and enhances the effect of local anaesthetics in …

Actions of noradrenaline on substantia gelatinosa neurones in the rat spinal cord revealed by in vivo patch recording

…, T Yasaka, A Doi, E Kumamoto… - The Journal of …, 2004 - Wiley Online Library
To elucidate the mechanisms of antinociception mediated by the descending noradrenergic
pathway in the spinal cord, the effects of noradrenaline (NA) on noxious synaptic responses …

[HTML][HTML] Bisphenol A inhibits compound action potentials in the frog sciatic nerve in a manner independent of estrogen receptors

K Mizuta, T Fujita, H Yamagata, E Kumamoto - … and Biophysics Reports, 2017 - Elsevier
Although the endocrine disruptor bisphenol A (BPA) is reported to inhibit nerve conduction,
the underlying mechanisms are unclear. Therefore, in the present study, we examined the …

Mechanisms for ovariectomy-induced hyperalgesia and its relief by calcitonin: participation of 5-HT1A-like receptor on C-afferent terminals in substantia gelatinosa of …

A Ito, E Kumamoto, M Takeda, M Takeda… - Journal of …, 2000 - Soc Neuroscience
Chronic treatment with calcitonin in osteoporotic patients alleviates the pain associated with
this condition by an unknown mechanism. In ovariectomized rats that develop osteoporosis …

Actions of midazolam on GABAergic transmission in substantia gelatinosa neurons of adult rat spinal cord slices

T Kohno, E Kumamoto, H Baba, T Ataka… - The Journal of the …, 2000 - pubs.asahq.org
Background Although intrathecal administration of midazolam has been found to produce
analgesia, how midazolam exerts this effect is not understood fully at the neuronal level in the …

Presynaptic inhibition by baclofen of miniature EPSCs and IPSCs in substantia gelatinosa neurons of the adult rat spinal dorsal horn

M Iyadomi, I Iyadomi, E Kumamoto, K Tomokuni… - Pain, 2000 - journals.lww.com
Intrathecal administration of baclofen, a GABA B-receptor agonist, affects pain behavior induced
by formalin in a biphasic manner; baclofen at low doses enhances pain while producing …

[HTML][HTML] Cellular mechanisms for antinociception produced by oxytocin and orexins in the rat spinal lamina II—Comparison with those of other endogenous pain …

E Kumamoto - Pharmaceuticals, 2019 - mdpi.com
Much evidence indicates that hypothalamus-derived neuropeptides, oxytocin, orexins A and
B, inhibit nociceptive transmission in the rat spinal dorsal horn. In order to unveil cellular …