Reduced dietary protein intake induces adaptive physiological changes in macronutrient
preference, energy expenditure, growth, and glucose homeostasis. We demonstrate that …

Dietary protein restriction is increasingly recognized as a unique approach to improve
metabolic health, and there is increasing interest in the mechanisms underlying this beneficial …

The preoptic area (POA) regulates body temperature, but is not considered a site for body
weight control. A subpopulation of POA neurons express leptin receptors (LepRb POA neurons…

The lateral hypothalamus (LHA) integrates reward and appetitive behavior and is composed
of many overlapping neuronal populations. Recent studies associated LHA GABAergic …

The ability to respond to variations in nutritional status depends on regulatory systems that
monitor nutrient intake and adaptively alter metabolism and feeding behavior during nutrient …

Objective Leptin modulates food reward via central leptin receptor (LepRb) expressing
neurons. Food reward requires stimulation of midbrain dopamine neurons and is modulated by …

The recent discovery of significant brown fat depots in adult humans has revived discussion
of exploiting brown fat thermogenesis in the control of energy balance and body weight. The …

The continuous rise in obesity is a major concern for future healthcare management. Many
strategies to control body weight focus on a permanent modification of food intake with limited …

Neurons expressing nitric oxide (NO) synthase (nNOS) and thus capable of synthesizing
NO play major roles in many aspects of brain function. While the heterogeneity of nNOS‐…

Glucagon‐like peptide‐1 (GLP‐1) is a neuropeptide released following meal ingestion that,
among other effects, decreases gastric tone and motility. The central targets and mechanism …