The detection and processing of painful stimuli in afferent sensory neurons is critically dependent
on a wide range of different types of voltage- and ligand-gated ion channels, including …

The modulation of voltage-dependent Ca 2+ channels at presynaptic nerve terminals is an
important factor in the control of neurotransmitter release and synaptic efficacy. Some …

Cold hypersensitivity is the hallmark of oxaliplatin‐induced neuropathy, which develops in
nearly all patients under this chemotherapy. To date, pain management strategies have failed …

The T-type calcium channel Cav3.2 emerges as a key regulator of sensory functions, but its
expression pattern within primary afferent neurons and its contribution to modality-specific …

The inhibition of N-type calcium channels by opioid receptor like receptor 1 (ORL1) is a key
mechanism for controlling the transmission of nociceptive signals. We recently reported that …

This review examines recent preclinical research on toxic peripheral neuropathy and potential
therapeutic developments. Chemotherapy-induced peripheral neurotoxicity is a major …

The spontaneous activity of pacemaker cells in the sino-atrial node controls the heart rhythm
and rate under physiological conditions. Compared to working myocardial cells, pacemaker …

The spontaneous activity of pacemaker cells in the sino-atrial node (SAN) controls the heart
rhythm and rate under physiological conditions. Pacemaker activity in SAN cells is due to the …

P-type and Q-type calcium channels mediate neurotransmitter release at many synapses in
the mammalian nervous system. The α 1A calcium channel has been implicated in the …

Analgesic therapies are still limited and sometimes poorly effective, therefore finding new
targets for the development of innovative drugs is urgently needed. In order to validate the …