The discovery that some cases of familial amyotrophic lateral sclerosis (FALS) are associated
with mutations in the gene encoding Cu/Zn superoxide dismutase (SOD1) has focused …

α-Synuclein accumulation and mitochondrial dysfunction have both been strongly implicated
in the pathogenesis of Parkinson’s disease (PD), and the two appear to be related. …

Apoptotic neuronal cell death has recently been associated with the development of
infarction after cerebral ischemia. In a variety of studies, CuZn-superoxide dismutase (CuZn-SOD) …

Missense mutations in leucine-rich repeat kinase 2 (LRRK2) cause familial Parkinson’s
disease (PD). However, a potential role of wild-type LRRK2 in idiopathic PD (iPD) remains …

Reactive oxygen species (ROS) such as superoxide, peroxide and hydroxyl radicals are
generated during normal cellular metabolism and are increased in acute injury and in many …

More than 80 years after iron accumulation was initially described in the substantia nigra (SN)
of Parkinson's disease (PD) patients, the mechanisms responsible for this phenomenon …

To investigate the roles of CuZn superoxide dismutase (CuZnSOD) and Mn superoxide
dismutase (MnSOD) in oxygen radical-mediated cytotoxicity and to distinguish the actions of …

The role of oxidative damage in neurodegenerative disease was investigated in mice lacking
cytoplasmic Cu/Zn superoxide dismutase (SOD), created by deletion of the SOD1 gene (…

Mitochondrial dysfunction and oxidative stress are strongly implicated in Parkinson's disease
(PD) pathogenesis and there is evidence that mitochondrially-generated superoxide can …

Point mutations occurring within the Cu Zn superoxide dismutase (SOD1) gene have been
implicated in the etiology of some cases of familial amyotrophic lateral sclerosis (FALS). In …