Cisplatin is one of the most effective and widely used anticancer agents for the treatment of
several types of tumors. The cytotoxic effect of cisplatin is thought to be mediated primarily by …

Integrin-mediated reorganization of cell shape leads to an altered cellular phenotype. Disruption
of the actin cytoskeleton, initiated by binding of soluble antibody to α5β1 integrin, led to …

We show here the transient activation of the small GTPase Rac, followed by a rise in reactive
oxygen species (ROS), as necessary early steps in a signal transduction cascade that lead …

MicroRNA-21 (miR-21) is an oncomir overexpressed in most human tumors in that it promotes
malignant growth and progression by acting on multiple targets. Here, we broaden the …

DNA double-strand break (DSB) repair by homologous recombination (HR) is initiated by
CtIP/MRN-mediated DNA end resection to maintain genome integrity. SAMHD1 is a dNTP …

OBJECTIVE: We sought to characterize serum angiogenic factor profile of women with
complete placenta previa and determine if invasive trophoblast differentiation characteristic of …

Mutational analyses have revealed many genes that are required for proper biogenesis of
lysosomes and lysosome-related organelles. The proteins encoded by these genes assemble …

Human papillomavirus (HPV) is the causative agent of a subgroup of head and neck cancer
characterized by an intrinsic radiosensitivity. HPV initiates cellular transformation through …

Tumor endothelial marker 8 (TEM8) is induced in tumor-associated vasculature and acts as
a receptor for Protective Antigen (PA), the cell-binding component of the anthrax toxin …

Synaptic vesicles (SV) are generated by two different mechanisms, one AP-2 dependent and
one AP-3 dependent. It has been uncertain, however, whether these mechanisms generate …