The tumour microenvironment plays a critical role in determining tumour fate. Within that
environment, and indeed throughout epithelial tissues, cells experience competition with their …

Epithelial cells migrate across wounds to repair injured tissue. Leader cells at the front of
migrating sheets often drive this process. However, it is unclear how leaders emerge from an …

In most cancers, transformation begins in a single cell in an epithelial cell sheet 1 , 2 , 3 .
However, it is not known what happens at the interface between non-transformed (normal) and …

Within tissues, cells sense differences in fitness levels and this can lead to fitter cells eliminating
less fit, albeit viable, cells via competitive cell interactions. The involvement of several …

Cell competition is a quality control mechanism that eliminates unfit cells. How cells compete
is poorly understood, but it is generally accepted that molecular exchange between cells …

Cell competition allows winner cells to eliminate less fit loser cells in tissues. In Minute cell
competition, cells with a heterozygous mutation in ribosome genes, such as RpS3 +/− cells, …

Gem belongs to the Rad/Gem/Kir (RGK) subfamily of Ras‐related GTPases, which also
comprises Rem, Rem2 and Ges. The RGK family members Ges and Rem have been shown to …

The Myc promoter-binding protein-1 (MBP-1) is a 37–38 kDa protein that binds to the c-myc
P2 promoter and negatively regulates transcription of the protooncogene. MBP-1 cDNA …

Tumor-host interactions play an increasingly recognized role in modulating tumor growth.
Thus, understanding the nature and impact of this complex bidirectional communication is key …

Endocytosis, with subsequent targeting to lysosomes for degradation, is traditionally seen as
a way for cells to terminate signalling. However, in a few instances, endocytosis has been …