Integrin-mediated dendrite branch maintenance requires Abelson (Abl) family kinases

EMY Moresco, S Donaldson, A Williamson… - Journal of …, 2005 - Soc Neuroscience
Dendrite arbor structure is a critical determinant of nervous system function that must be
actively maintained throughout life, but the signaling pathways that regulate dendrite …

Abl family nonreceptor tyrosine kinases modulate short-term synaptic plasticity

EMY Moresco, AJ Scheetz… - Journal of …, 2003 - journals.physiology.org
Abl family nonreceptor tyrosine kinases regulate cell morphogenesis through functional
interactions with the actin cytoskeleton. The vertebrate Abl family kinases, Abl and Arg, are …

Next-Generation Diprovocims with Potent Human and Murine TLR1/TLR2 Agonist Activity That Activate the Innate and Adaptive Immune Response

…, Y Mifune, Y Wang, H Shi, EMY Moresco… - Journal of medicinal …, 2022 - ACS Publications
The diprovocims, a new class of toll-like receptor (TLR) agonists, bear no similarity to prior
TLR agonists, act through a well-defined mechanism (TLR1/TLR2 agonist), exhibit exquisite …

Genetic and structural studies of RABL3 reveal an essential role in lymphoid development and function

…, CA Brautigam, EMY Moresco… - Proceedings of the …, 2020 - National Acad Sciences
The small GTPase RABL3 is an oncogene of unknown physiological function. Homozygous
knockout alleles of mouse Rabl3 were embryonic lethal, but a viable hypomorphic allele (…

Real-time resolution of point mutations that cause phenovariance in mice

…, M Tang, X Li, L Scott, EMY Moresco… - Proceedings of the …, 2015 - National Acad Sciences
With the wide availability of massively parallel sequencing technologies, genetic mapping
has become the rate limiting step in mammalian forward genetics. Here we introduce a …

The serine protease TMPRSS6 is required to sense iron deficiency

…, Y Xia, K Khovananth, S Mudd, N Mann, EMY Moresco… - Science, 2008 - science.org
Hepcidin, a liver-derived protein that restricts enteric iron absorption, is the key regulator of
body iron content. Several proteins induce expression of the hepcidin-encoding gene Hamp …

[HTML][HTML] Current strategies for mutation detection in phenotype-driven screens utilising next generation sequencing

MM Simon, EMY Moresco, KR Bull, S Kumar… - Mammalian …, 2015 - Springer
Mutagenesis-based screens in mice are a powerful discovery platform to identify novel
genes or gene functions associated with disease phenotypes. An N-ethyl-N-nitrosourea (ENU) …

Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger

…, AL Blasius, EMY Moresco… - Proceedings of the …, 2008 - National Acad Sciences
A recessive phenotype called spin (spontaneous inflammation) was induced by N-ethyl-N-nitrosourea
(ENU) mutagenesis in C57BL/6J mice. Homozygotes display chronic …

SLFN2 protection of tRNAs from stress-induced cleavage is essential for T cell–mediated immunity

…, D Xu, X Li, E Turer, L Sun, EMY Moresco… - Science, 2021 - science.org
INTRODUCTION Naïve T cells activated by cognate antigens and costimulation proliferate
and differentiate to effector T cells. The shift from a resting to a proliferative state entails …

[HTML][HTML] Commitment to the regulatory T cell lineage requires CARMA1 in the thymus but not in the periphery

…, CN Arnold, K Crozat, S Sovath, EM Moresco… - PLoS …, 2009 - journals.plos.org
Regulatory T (T reg ) cells expressing forkhead box P3 (Foxp3) arise during thymic selection
among thymocytes with modestly self-reactive T cell receptors. In vitro studies suggest …