HER2-positive breast cancer accounts for 20–30% of all breast cancers and has the second-poorest
prognosis among breast cancer subtypes. The approval of trastuzumab in 1998 has …

Immune check point blockade therapy has revolutionized the standard of cancer treatment
and is credited with producing remarkable tumor remissions and increase in overall survival. …

c-Jun activation domain-binding protein-1 (Jab1) acts as a modulator of intracellular signaling
and affects cellular proliferation and apoptosis, through its existence as a monomer or as …

The Rho subfamily of GTPases is involved in controlof cell morphology in mammals and yeast.
The mammalian Rac and Cdc42 proteins control formation of lamellipodia and filopodia, …

… Each bar represents the percentage of positive Cells expressing f-galactosidase from 2–3
experiments where 100–200 cells were injected in each. [anti-CBP), Concentration of affinity-…

One Ras-dependent protein kinase cascade leading from growth factor receptors to the
ERK (extracellular signal-regulated kinases) subgroup of mitogen-activated protein kinases (…

Growth factors induce c‐fos transcription by stimulating phosphorylation of transcription factor
TCF/Elk‐1, which binds to the serum response element (SRE). Under such conditions Elk‐…

… 5 x 10" cells were transfected with 100 ng receptor expression plasmid, 500 ng reporter and
500 ng f-galactosidase (B-gal) expression plasmid (internal control). Transfected cells were …

The efficacy of cisplatin in cancer chemotherapy is limited by the development of resistance.
Although the molecular mechanisms involved in chemoresistance are poorly understood, …

… In situ hybridization using probes for FasL (A to C) and c-jun (D to F) mRNAs was performed
on … As a specificity control, the cells in panels C and F were hybridized to the probes in the …