Background: Negative symptoms may be associated with dysfunction of the brain reward
system in schizophrenia. We used functional magnetic resonance imaging (fMRI) to assess the …

OBJECTIVE: Alcohol dependence may be associated with dysfunction of mesolimbic circuitry,
such that anticipation of nonalcoholic reward fails to activate the ventral striatum, while …

BACKGROUND: Alcohol dependence is often associated with impulsivity, which may be
correlated with dysfunction of the brain reward system. We explored whether functional brain …

A dysregulation of the mesolimbic dopamine system in schizophrenia patients may lead to
aberrant attribution of incentive salience and contribute to the emergence of …

The orbitofrontal cortex has been cytoarchitectonically and connectionally subdivided into a
medial and a lateral part which are assumed to subserve distinct functions in emotional …

Attention-deficit/hyperactivity disorder (ADHD) has been suggested to involve deficits in
reward processing. We used functional magnetic resonance imaging (fMRI) to compare the …

Rational Clinical studies in patients with schizophrenia suggest that atypical neuroleptics
are more effective than typical neuroleptics in reducing negative symptoms including apathy …

Importance Abnormal reward processing is suggested to underlie the formation of psychotic
symptoms, likely driven by elevated ventral striatal (VS) dopamine levels. Functional …

Context In alcohol-dependent patients, brain atrophy and functional brain activation elicited
by alcohol-associated stimuli may predict relapse. However, to date, the interaction between …

Dual system theories suggest that behavioral control is parsed between a deliberative “model-based”
and a more reflexive “model-free” system. A balance of control exerted by these …