User profiles for Frank M. LaFerla
Frank LaFerlaDean, University of California, Irvine Verified email at uci.edu Cited by 59793 |
[PDF][PDF] Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Aβ and synaptic dysfunction
The neuropathological correlates of Alzheimer's disease (AD) include amyloid-β (Aβ) plaques
and neurofibrillary tangles. To study the interaction between Aβ and tau and their effect on …
and neurofibrillary tangles. To study the interaction between Aβ and tau and their effect on …
Alzheimer's disease
HW Querfurth, FM LaFerla - New England Journal of Medicine, 2010 - Mass Medical Soc
This review of Alzheimer's disease assembles a variety of findings relevant to the mechanism
of the disease and ties them together using the current understanding of the basis of the …
of the disease and ties them together using the current understanding of the basis of the …
Intracellular amyloid-β in Alzheimer's disease
The primal role that the amyloid-β (Aβ) peptide has in the development of Alzheimer's disease
is now almost universally accepted. It is also well recognized that Aβ exists in multiple …
is now almost universally accepted. It is also well recognized that Aβ exists in multiple …
[PDF][PDF] Intraneuronal Aβ causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice
Progressive memory loss and cognitive dysfunction are the hallmark clinical features of
Alzheimer's disease (AD). Identifying the molecular triggers for the onset of AD-related cognitive …
Alzheimer's disease (AD). Identifying the molecular triggers for the onset of AD-related cognitive …
Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease
Amyloid-β (Aβ) containing plaques and tau-laden neurofibrillary tangles are the defining
neuropathological features of Alzheimer’s disease (AD). To better mimic this neuropathology, …
neuropathological features of Alzheimer’s disease (AD). To better mimic this neuropathology, …
Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease
FM LaFerla - Nature Reviews Neuroscience, 2002 - nature.com
Calcium modulates many neural processes, including synaptic plasticity and apoptosis.
Dysregulation of intracellular calcium signalling has been implicated in the pathogenesis of …
Dysregulation of intracellular calcium signalling has been implicated in the pathogenesis of …
Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease
Neural stem cell (NSC) transplantation represents an unexplored approach for treating
neurodegenerative disorders associated with cognitive decline such as Alzheimer disease (AD). …
neurodegenerative disorders associated with cognitive decline such as Alzheimer disease (AD). …
[PDF][PDF] Aβ immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome
Amyloid-β (Aβ) plaques and neurofibrillary tangles are the hallmark neuropathological
lesions of Alzheimer's disease (AD). Using a triple transgenic model (3xTg-AD) that develops …
lesions of Alzheimer's disease (AD). Using a triple transgenic model (3xTg-AD) that develops …
Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease
Inflammation is a critical component of the pathogenesis of Alzheimer's disease (AD). Although
not an initiator of this disorder, inflammation nonetheless plays a pivotal role as a driving …
not an initiator of this disorder, inflammation nonetheless plays a pivotal role as a driving …
Glucocorticoids increase amyloid-β and tau pathology in a mouse model of Alzheimer's disease
…, B Roozendaal, JL McGaugh, FM LaFerla - Journal of …, 2006 - Soc Neuroscience
Various environmental and genetic factors influence the onset and progression of Alzheimer’s
disease (AD). Dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis, which …
disease (AD). Dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis, which …