User profiles for Frank M. LaFerla

Frank LaFerla

Dean, University of California, Irvine
Verified email at uci.edu
Cited by 59793

[PDF][PDF] Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Aβ and synaptic dysfunction

…, R Metherate, MP Mattson, Y Akbari, FM LaFerla - Neuron, 2003 - cell.com
The neuropathological correlates of Alzheimer's disease (AD) include amyloid-β (Aβ) plaques
and neurofibrillary tangles. To study the interaction between Aβ and tau and their effect on …

Alzheimer's disease

HW Querfurth, FM LaFerla - New England Journal of Medicine, 2010 - Mass Medical Soc
This review of Alzheimer's disease assembles a variety of findings relevant to the mechanism
of the disease and ties them together using the current understanding of the basis of the …

Intracellular amyloid-β in Alzheimer's disease

FM LaFerla, KN Green, S Oddo - Nature Reviews Neuroscience, 2007 - nature.com
The primal role that the amyloid-β (Aβ) peptide has in the development of Alzheimer's disease
is now almost universally accepted. It is also well recognized that Aβ exists in multiple …

[PDF][PDF] Intraneuronal Aβ causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice

…, S Oddo, KN Green, JL McGaugh, FM LaFerla - Neuron, 2005 - cell.com
Progressive memory loss and cognitive dysfunction are the hallmark clinical features of
Alzheimer's disease (AD). Identifying the molecular triggers for the onset of AD-related cognitive …

Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease

…, A Caccamo, M Kitazawa, BP Tseng, FM LaFerla - Neurobiology of …, 2003 - Elsevier
Amyloid-β (Aβ) containing plaques and tau-laden neurofibrillary tangles are the defining
neuropathological features of Alzheimer’s disease (AD). To better mimic this neuropathology, …

Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease

FM LaFerla - Nature Reviews Neuroscience, 2002 - nature.com
Calcium modulates many neural processes, including synaptic plasticity and apoptosis.
Dysregulation of intracellular calcium signalling has been implicated in the pathogenesis of …

Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease

…, WW Poon, KN Green, FM LaFerla - Proceedings of the …, 2009 - National Acad Sciences
Neural stem cell (NSC) transplantation represents an unexplored approach for treating
neurodegenerative disorders associated with cognitive decline such as Alzheimer disease (AD). …

[PDF][PDF] Aβ immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome

S Oddo, L Billings, JP Kesslak, DH Cribbs, FM LaFerla - Neuron, 2004 - cell.com
Amyloid-β (Aβ) plaques and neurofibrillary tangles are the hallmark neuropathological
lesions of Alzheimer's disease (AD). Using a triple transgenic model (3xTg-AD) that develops …

Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease

…, TR Yamasaki, KN Green, FM LaFerla - Journal of …, 2005 - Soc Neuroscience
Inflammation is a critical component of the pathogenesis of Alzheimer's disease (AD). Although
not an initiator of this disorder, inflammation nonetheless plays a pivotal role as a driving …

Glucocorticoids increase amyloid-β and tau pathology in a mouse model of Alzheimer's disease

…, B Roozendaal, JL McGaugh, FM LaFerla - Journal of …, 2006 - Soc Neuroscience
Various environmental and genetic factors influence the onset and progression of Alzheimer’s
disease (AD). Dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis, which …