Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11. 2
To identify susceptibility loci for schizophrenia, we performed a two-stage genome-wide
association study (GWAS) of schizophrenia in the Han Chinese population (GWAS: 746 …
association study (GWAS) of schizophrenia in the Han Chinese population (GWAS: 746 …
VPS35 haploinsufficiency increases Alzheimer's disease neuropathology
VPS35, a major component of the retromer complex, is important for endosome-to-Golgi
retrieval of membrane proteins. Although implicated in Alzheimer’s disease (AD), how VPS35 …
retrieval of membrane proteins. Although implicated in Alzheimer’s disease (AD), how VPS35 …
[PDF][PDF] VPS35 deficiency or mutation causes dopaminergic neuronal loss by impairing mitochondrial fusion and function
Vacuolar protein sorting-35 (VPS35) is a retromer component for endosomal trafficking.
Mutations of VPS35 have been linked to familial Parkinson's disease (PD). Here, we show that …
Mutations of VPS35 have been linked to familial Parkinson's disease (PD). Here, we show that …
VPS35 in dopamine neurons is required for endosome-to-Golgi retrieval of Lamp2a, a receptor of chaperone-mediated autophagy that is critical for α-synuclein …
Vacuolar protein sorting-35 (VPS35) is essential for endosome-to-Golgi retrieval of membrane
proteins. Mutations in the VPS35 gene have been identified in patients with autosomal …
proteins. Mutations in the VPS35 gene have been identified in patients with autosomal …
[HTML][HTML] YAP promotes osteogenesis and suppresses adipogenic differentiation by regulating β-catenin signaling
YAP (yes-associated protein) is a transcriptional factor that is negatively regulated by Hippo
pathway, a conserved pathway for the development and size control of multiple organs. The …
pathway, a conserved pathway for the development and size control of multiple organs. The …
Neuron-derived estrogen is critical for astrocyte activation and neuroprotection of the ischemic brain
17β-Estradiol (E2) is produced from androgens via the action of the enzyme aromatase. E2
is known to be made in neurons in the brain, but the functions of neuron-derived E2 in the …
is known to be made in neurons in the brain, but the functions of neuron-derived E2 in the …
[HTML][HTML] VPS35-deficiency results in an impaired AMPA receptor trafficking and decreased dendritic spine maturation
Background Vacuolar protein sorting 35 (VPS35), a key component of retromer, plays an
important role in endosome-to-Golgi retrieval of membrane proteins. Dysfunction of VPS35/…
important role in endosome-to-Golgi retrieval of membrane proteins. Dysfunction of VPS35/…
VPS35 regulates developing mouse hippocampal neuronal morphogenesis by promoting retrograde trafficking of BACE1
VPS35, a major component of the retromer, plays an important role in the selective
endosome-to-Golgi retrieval of membrane proteins. Dysfunction of retromer is a risk factor for …
endosome-to-Golgi retrieval of membrane proteins. Dysfunction of retromer is a risk factor for …
Neogenin promotes BMP2 activation of YAP and Smad1 and enhances astrocytic differentiation in developing mouse neocortex
Z Huang, D Sun, JX Hu, FL Tang, DH Lee… - Journal of …, 2016 - Soc Neuroscience
Neogenin, a DCC (deleted in colorectal cancer) family receptor, is highly expressed in neural
stem cells (NSCs). However, its function in NSCs remains to be explored. Here we provide …
stem cells (NSCs). However, its function in NSCs remains to be explored. Here we provide …
[HTML][HTML] Coupling of terminal differentiation deficit with neurodegenerative pathology in Vps35-deficient pyramidal neurons
Vps35 (vacuolar protein sorting 35) is a key component of retromer that regulates transmembrane
protein trafficking. Dysfunctional Vps35 is a risk factor for neurodegenerative diseases, …
protein trafficking. Dysfunctional Vps35 is a risk factor for neurodegenerative diseases, …