Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the
neuronal compartment, but includes strong interactions with immunological mechanisms in …

Alzheimer’s disease (AD) is associated with impaired clearance of β-amyloid (Aβ) from the
brain, a process normally facilitated by apolipoprotein E (apoE). ApoE expression is …

Apolipoprotein E is associated with age-related risk for Alzheimer's disease and plays
critical roles in Aβ homeostasis. We report that ApoE plays a role in facilitating the proteolytic …

Reactive microglia associated with the β-amyloid plaques in Alzheimer's disease (AD)
brains initiate a sequence of inflammatory events integral to the disease process. We have …

Alzheimer's disease (AD) is characterized by the extracellular deposition of β-amyloid fibrils
within the brain and the subsequent association and phenotypic activation of microglial cells …

Post-traumatic cystic cavitation, in which the size and severity of a CNS injury progress from
a small area of direct trauma to a greatly enlarged secondary injury surrounded by glial scar …

Alzheimer’s disease (AD), the most prominent cause of senile dementia, is clinically
characterized by the extracellular deposition of β-amyloid (Aβ) and the intracellular neurofibrillary …

Senile plaques found in the Alzheimer's disease brain are foci of local inflammatory reactions
mediated by plaque-associated microglia. The interaction of microglia with compacted …

Neuritic plaques in the brain of Alzheimer's disease patients are characterized by β-amyloid
deposits associated with a glia-mediated inflammatory response. Non-steroidal anti-…

Variants in triggering receptor expressed on myeloid cells 2 (TREM2) confer high risk for
Alzheimer’s disease (AD) and other neurodegenerative diseases. However, the cell types and …