Angiogenesis, the formation of vessels from pre‐existing vessels, is of critical importance not
only during normal growth, but also in pathological situations. In the latter, some diseases …

… We have found that complete blockade of Tie-2 leads to rapid EC precursor death in culture
(GC Schatteman and C. Jao, unpublished observations). In vivo, CD34 + BMD cell tend to …

Cutaneous melanoma has been increasing at an alarming rate over the past two decades,
however, there are no acceptable histopathological markers that classify various stages of …

Endothelial cell progenitors, angioblasts, have been detected in the peripheral blood of
adult humans, mice, and rabbits. These cells have been shown to incorporate into the …

We recently have introduced the term vasculogenic mimicry to describe the unique ability of
aggressive melanoma tumor cells to form tubular structures and patterned networks in three-…

… whereas highly proliferative EC have been reported in other leukocyte culture systems [5,
6] and we find that at high-density blood-derived EC are proliferative [Harraz and Schatteman, …

The Patch (Ph) mutation in mice is a deletion of the gene encoding the platelet-derived
growth factor receptor alpha subunit (PDGFR α). Patch is a recessive lethal recognized in …

The platelet-derived growth factor receptor a-subunit (PDGFR α) is the form of the PDGF
receptor that is required for binding of PDGF A-chain. Expression of PDGFR α within the early …

Diabetes is characterized by poor circulation and impaired angiogenesis, which appear to
contribute to the frequent skin lesions and poor wound healing common in diabetic patients. …

On the basis of the ability of aggressive melanoma cells to participate in vasculogenic mimicry,
particularly their expression of endothelial-associated genes, we examined the plasticity …