Calorie restriction mimetics: an emerging research field

…, M Zhu, J Mamczarz, S Zou, MA Lane, GS Roth… - Aging cell, 2006 - Wiley Online Library
When considering all possible aging interventions evaluated to date, it is clear that calorie
restriction (CR) remains the most robust. Studies in numerous species have demonstrated that …

Caloric restriction in primates and relevance to humans

GS Roth, DK Ingram, MA Lane - … of the New York Academy of …, 2001 - Wiley Online Library
Dietary caloric restriction (CR) is the only intervention conclusively and reproducibly shown
to slow aging and maintain health and vitality in mammals. Although this paradigm has been …

Development of calorie restriction mimetics as a prolongevity strategy

…, MIN Zhu, J Mattison, MA Lane, GS Roth - Annals of the New …, 2004 - Wiley Online Library
By applying calorie restriction (CR) at 30‐50% below ad libitum levels, studies in numerous
species have reported increased life span, reduced incidence and delayed onset of age‐…

Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study

JA Mattison, GS Roth, TM Beasley, EM Tilmont… - Nature, 2012 - nature.com
Calorie restriction (CR), a reduction of 10–40% in intake of a nutritious diet, is often reported
as the most robust non-genetic mechanism to extend lifespan and healthspan. CR is …

[HTML][HTML] Caloric restriction improves health and survival of rhesus monkeys

…, TM Beasley, DB Allison, JW Kemnitz, GS Roth… - Nature …, 2017 - nature.com
Caloric restriction (CR) without malnutrition extends lifespan and delays the onset of age-related
disorders in most species but its impact in nonhuman primates has been controversial. …

Biomarkers of caloric restriction may predict longevity in humans

GS Roth, MA Lane, DK Ingram, JA Mattison, D Elahi… - Science, 2002 - science.org
These findings include CR-induced attenuation of age changes in plasma triglycerides (2)
and melatonin (3) as well as oxidative damage (4) and glucose tolerance (5). Current …

[HTML][HTML] Extending the lifespan of long-lived mice

…, JC Wright, JA Mattison, DK Ingram, RA Miller, GS Roth - Nature, 2001 - nature.com
Ames dwarf mice are mutant mice that live about 50% longer than their normal siblings 1 , 2
, 3 because they carry a 'longevity' gene, Prop1 df , and in some phenotypic respects they …

Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease

…, GA Gerhardt, R Grondin, GS Roth… - Proceedings of the …, 2004 - National Acad Sciences
We report that a low-calorie diet can lessen the severity of neurochemical deficits and motor
dysfunction in a primate model of Parkinson's disease. Adult male rhesus monkeys were …

Aging in rhesus monkeys: relevance to human health interventions

GS Roth, JA Mattison, MA Ottinger, ME Chachich… - Science, 2004 - science.org
Progress in gerontological research has been promoted through the use of numerous animal
models, which have helped identify possible mechanisms of aging and age-related chronic …

Calorie restriction lowers body temperature in rhesus monkeys, consistent with a postulated anti-aging mechanism in rodents.

…, EM Tilmont, RG Cutler, GS Roth - Proceedings of the …, 1996 - National Acad Sciences
Many studies of caloric restriction (CR) in rodents and lower animals indicate that this nutritional
manipulation retards aging processes, as evidenced by increased longevity, reduced …