Carbon monoxide: a putative neural messenger
A Verma, DJ Hirsch, CE Glatt, GV Ronnett, SH Snyder - Science, 1993 - science.org
Carbon monoxide, an activator of guanylyl cyclase, is formed by the action of the enzyme
heme oxygenase. By in situ hybridization in brain slices, discrete neuronal localization of …
heme oxygenase. By in situ hybridization in brain slices, discrete neuronal localization of …
Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors
…, GL Frehywot, CA Townsend, GV Ronnett… - Science, 2000 - science.org
With the escalation of obesity-related disease, there is great interest in defining the
mechanisms that control appetite and body weight. We have identified a link between anabolic …
mechanisms that control appetite and body weight. We have identified a link between anabolic …
[HTML][HTML] Pharmacological inhibition of AMP-activated protein kinase provides neuroprotection in stroke
…, H Li, LE Landree, J McFadden, GV Ronnett - Journal of Biological …, 2005 - ASBMB
The restoration of energy balance during ischemia is critical to cellular survival; however,
relatively little is known concerning the regulation of neuronal metabolic pathways in response …
relatively little is known concerning the regulation of neuronal metabolic pathways in response …
AMPK in the brain: its roles in energy balance and neuroprotection
GV Ronnett, S Ramamurthy, AM Kleman… - Journal of …, 2009 - Wiley Online Library
Adenosine monophosphate‐activated protein kinase (AMPK) senses metabolic stress and
integrates diverse physiological signals to restore energy balance. Multiple functions are …
integrates diverse physiological signals to restore energy balance. Multiple functions are …
[HTML][HTML] C75, a fatty acid synthase inhibitor, reduces food intake via hypothalamic AMP-activated protein kinase
…, FP Kuhajda, TH Moran, GV Ronnett - Journal of Biological …, 2004 - ASBMB
Energy homeostasis and feeding are regulated by the central nervous system. C75, a fatty
acid synthase (FAS) inhibitor, causes weight loss and anorexia, implying a novel central …
acid synthase (FAS) inhibitor, causes weight loss and anorexia, implying a novel central …
C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity
JN Thupari, LE Landree, GV Ronnett… - Proceedings of the …, 2002 - National Acad Sciences
C75, a known inhibitor of fatty acid synthase is postulated to cause significant weight loss
through decreased hypothalamic neuropeptide Y (NPY) production. Peripherally, C75, an α-…
through decreased hypothalamic neuropeptide Y (NPY) production. Peripherally, C75, an α-…
Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells
…, SM Medghalchi, A Vadlamudi, ML Pinn, GV Ronnett… - Cancer research, 2003 - AACR
C75, an inhibitor of fatty acid synthase (FAS), induces apoptosis in cultured human cancer
cells. Its proposed mechanism of action linked high levels of malonyl-CoA after FAS inhibition …
cells. Its proposed mechanism of action linked high levels of malonyl-CoA after FAS inhibition …
Neuroprotective effects of adenosine monophosphate-activated protein kinase inhibition and gene deletion in stroke
J Li, Z Zeng, B Viollet, GV Ronnett, LD McCullough - Stroke, 2007 - Am Heart Assoc
Background and Purpose— 5′ adenosine monophosphate-dependent protein kinase (AMPK)
acts as a metabolic sensor. AMPK is elevated under ischemic conditions, but the role of …
acts as a metabolic sensor. AMPK is elevated under ischemic conditions, but the role of …
The native rat olfactory cyclic nucleotide-gated channel is composed of three distinct subunits
Cyclic nucleotide-gated (CNG) channels play central roles in visual and olfactory signal
transduction. In the retina, rod photoreceptors express the subunits CNCα1 and CNCβ1a. In …
transduction. In the retina, rod photoreceptors express the subunits CNCα1 and CNCβ1a. In …
[HTML][HTML] Carbon monoxide: an endogenous modulator of the nitric oxide–cyclic GMP signaling system
T Ingi, J Cheng, GV Ronnett - Neuron, 1996 - cell.com
Carbon monoxide (CO) is an activator of soluble guanylyl cyclase and is implicated as a
neuronal messenger. CO production, nitric oxide synthase (NOS) activity, and guanosine 3′,5…
neuronal messenger. CO production, nitric oxide synthase (NOS) activity, and guanosine 3′,5…