Carbon monoxide, an activator of guanylyl cyclase, is formed by the action of the enzyme
heme oxygenase. By in situ hybridization in brain slices, discrete neuronal localization of …

With the escalation of obesity-related disease, there is great interest in defining the
mechanisms that control appetite and body weight. We have identified a link between anabolic …

The restoration of energy balance during ischemia is critical to cellular survival; however,
relatively little is known concerning the regulation of neuronal metabolic pathways in response …

Adenosine monophosphate‐activated protein kinase (AMPK) senses metabolic stress and
integrates diverse physiological signals to restore energy balance. Multiple functions are …

Energy homeostasis and feeding are regulated by the central nervous system. C75, a fatty
acid synthase (FAS) inhibitor, causes weight loss and anorexia, implying a novel central …

C75, a known inhibitor of fatty acid synthase is postulated to cause significant weight loss
through decreased hypothalamic neuropeptide Y (NPY) production. Peripherally, C75, an α-…

C75, an inhibitor of fatty acid synthase (FAS), induces apoptosis in cultured human cancer
cells. Its proposed mechanism of action linked high levels of malonyl-CoA after FAS inhibition …

Background and Purpose— 5′ adenosine monophosphate-dependent protein kinase (AMPK)
acts as a metabolic sensor. AMPK is elevated under ischemic conditions, but the role of …

Cyclic nucleotide-gated (CNG) channels play central roles in visual and olfactory signal
transduction. In the retina, rod photoreceptors express the subunits CNCα1 and CNCβ1a. In …

Carbon monoxide (CO) is an activator of soluble guanylyl cyclase and is implicated as a
neuronal messenger. CO production, nitric oxide synthase (NOS) activity, and guanosine 3′,5…