User profiles for Georges E. Grau

Georges Grau

Professor of Pathology, The University of Sydney
Verified email at med.usyd.edu.au
Cited by 40200

The inducing role of tumor necrosis factor in the development of bactericidal granulomas during BCG infection

V Kindler, AP Sappino, GE Grau, PF Piguet, P Vassalli - Cell, 1989 - cell.com
Granuloma formation in the liver of mice infected with BCG coincides with local TNF synthesis.
Injection of rabbit anti-TNF antibody, after 1 or 2 weeks of infection, dramatically interferes …

Diagnostic value of procalcitonin, interleukin-6, and interleukin-8 in critically ill patients admitted with suspected sepsis

…, C Froidevaux, D Pittet, B Ricou, GE Grau… - American journal of …, 2001 - atsjournals.org
To assess the diagnostic value of procalcitonin (PCT), interleukin (IL)-6, IL-8, and standard
measurements in identifying critically ill patients with sepsis, we performed prospective …

Tumor necrosis factor and disease severity in children with falciparum malaria

GE Grau, TE Taylor, ME Molyneux… - New England journal …, 1989 - Mass Medical Soc
To investigate the role of tumor necrosis factor in Plasmodium falciparum infections, we
measured serum concentrations of this cytokine in 65 Malawian children with severe falciparum …

Tumor necrosis factor (cachectin) as an essential mediator in murine cerebral malaria

GE Grau, LF Fajardo, PF Piguet, B Allet, PH Lambert… - Science, 1987 - science.org
Tumor necrosis factor, or cachectin (TNF-α), a protein with a wide range of biological activities,
is produced mainly by macrophages and may be important in inflammatory processes. …

Tumor necrosis factor and interleuktn-1 in the serum of children with severe infectious purpura

E Girardin, GE Grau, JM Dayer… - … England Journal of …, 1988 - Mass Medical Soc
Because of the possible involvement of cytokines in gram-negative septicemia, we investigated
serum levels of tumor necrosis factor alpha, interleukin-1 beta, alpha interferon, and …

[HTML][HTML] Immunological processes in malaria pathogenesis

L Schofield, GE Grau - Nature Reviews Immunology, 2005 - nature.com
Malaria is possibly the most serious infectious disease of humans, infecting 5–10% of the
world's population, with 300–600 million clinical cases and more than 2 million deaths annually…

Requirement of tumour necrosis factor for development of silica-induced pulmonary fibrosis

PF Piguet, MA Collart, GE Grau, AP Sappino, P Vassalli - Nature, 1990 - nature.com
THE deposition of silica particles in the lung of man or experimental animals leads to silicosis,
a disease of progressive respiratory failure caused by a fibrotic reaction 1 . It has long …

Tumor necrosis factor/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis.

PF Piguet, MA Collart, GE Grau, Y Kapanci… - The Journal of …, 1989 - rupress.org
The role of TNF-alpha/cachectin in the pneumopathy elicited by bleomycin has been
investigated. After a single intratracheal bleomycin instillation, an increase of the lung TNF-alpha …

High bronchoalveolar levels of tumor necrosis factor and its inhibitors, interleukin-1, interferon, and elastase, in patients with adult respiratory distress syndrome after …

…, S Suter, E Girardin, P Roux-Lombard, GE Grau… - Am Rev Respir …, 1992 - atsjournals.org
Intrapulmonary activation of leukocytes and release of cellular mediators and enzymes are
Involved In the pathophysiology of the adult respiratory distress syndrome (ARDS). To …

Prognostic values of tumor necrosis factor/cachectin, interleukin-l, interferon-α, and interferon-γ in the serum of patients with septic shock

T Calandra, JD Baumgartner, GE Grau… - Journal of Infectious …, 1990 - academic.oup.com
Serum concentrations of immunoreactive tumor necrosis factor/cachectin (TNF), interleukin-1β
(IL-1β), interferon-γ (IFNγ, and interferon-α (IFNα) were prospectively measured in 70 …