User profiles for Georgina MacKenzie
Georgina MackenzieTufts University Verified email at tufts.edu Cited by 1021 |
Neurosteroidogenesis is required for the physiological response to stress: role of neurosteroid-sensitive GABAA receptors
J Sarkar, S Wakefield, G MacKenzie… - Journal of …, 2011 - Soc Neuroscience
The hypothalamic-pituitary-adrenal (HPA) axis, which mediates the body's response to
stress, is largely under GABAergic control. Here we demonstrate that corticotropin-releasing …
stress, is largely under GABAergic control. Here we demonstrate that corticotropin-releasing …
Chronic stress shifts the GABA reversal potential in the hippocampus and increases seizure susceptibility
G MacKenzie, J Maguire - Epilepsy research, 2015 - Elsevier
The most commonly reported precipitating factor for seizures is stress. However, the
underlying mechanisms whereby stress triggers seizures are not yet fully understood. Here we …
underlying mechanisms whereby stress triggers seizures are not yet fully understood. Here we …
The role of ovarian hormone-derived neurosteroids on the regulation of GABAA receptors in affective disorders
G MacKenzie, J Maguire - Psychopharmacology, 2014 - Springer
Rationale Neuroactive derivatives of steroid hormones, neurosteroids, can act on GABA A
receptors (GABA A Rs) to potentiate the effects of GABA on these receptors. Neurosteroids …
receptors (GABA A Rs) to potentiate the effects of GABA on these receptors. Neurosteroids …
Profound desensitization by ambient GABA limits activation of δ-containing GABAA receptors during spillover
…, J Bartram, TP McGee, G MacKenzie… - Journal of …, 2011 - Soc Neuroscience
High-affinity extrasynaptic GABA A receptors (GABA A Rs) are a prominent feature of cerebellar
granule neurons and thalamic relay neurons. In both cell types, the presence of synaptic …
granule neurons and thalamic relay neurons. In both cell types, the presence of synaptic …
[HTML][HTML] Neurosteroids and GABAergic signaling in health and disease
G MacKenzie, J Maguire - Biomolecular concepts, 2013 - degruyter.com
… Georgina MacKenzie Georgina MacKenzie received her bachelor’s degree in Biochemistry
from the University of Bath (Bath, UK) in 2006. She then moved to Imperial College London (…
from the University of Bath (Bath, UK) in 2006. She then moved to Imperial College London (…
Subversion of actin dynamics by EspM effectors of attaching and effacing bacterial pathogens
A Arbeloa, RR Bulgin, G MacKenzie… - Cellular …, 2008 - Wiley Online Library
Rho GTPases are common targets of bacterial toxins and type III secretion system effectors.
IpgB1 and IpgB2 of Shigella and Map of enteropathogenic (EPEC) and enterohemorrhagic (…
IpgB1 and IpgB2 of Shigella and Map of enteropathogenic (EPEC) and enterohemorrhagic (…
Are extrasynaptic GABAA receptors important targets for sedative/hypnotic drugs?
CM Houston, TP McGee, G MacKenzie… - Journal of …, 2012 - Soc Neuroscience
High-affinity extrasynaptic GABA A receptors are persistently activated by the low ambient
GABA levels that are known to be present in extracellular space. The resulting tonic …
GABA levels that are known to be present in extracellular space. The resulting tonic …
Compromised GABAergic inhibition contributes to tumor-associated epilepsy
Glioblastoma Multiforme (GBM) is the most common form of primary brain tumor with 30–50%
of patients presenting with epilepsy. These tumor-associated seizures are often resistant to …
of patients presenting with epilepsy. These tumor-associated seizures are often resistant to …
Gαq-mediated regulation of TASK3 two-pore domain potassium channels: the role of protein kinase C
EL Veale, LE Kennard, GL Sutton, G MacKenzie… - Molecular …, 2007 - ASPET
The TASK subfamily of two pore domain potassium channels (K2P) gives rise to leak
potassium currents, which contribute to the resting membrane potential of many neurons and …
potassium currents, which contribute to the resting membrane potential of many neurons and …
Reduced tonic inhibition in the dentate gyrus contributes to chronic stress‐induced impairments in learning and memory
V Lee, G MacKenzie, A Hooper, J Maguire - Hippocampus, 2016 - Wiley Online Library
It is well established that stress impacts the underlying processes of learning and memory.
The effects of stress on memory are thought to involve, at least in part, effects on the …
The effects of stress on memory are thought to involve, at least in part, effects on the …