The serotonin (5-HT) hypothesis of schizophrenia arose from early studies on interactions
between the hallucinogenic drug LSD (d-lysergic acid diethylamide) and 5-HT in peripheral …

The influence of 5-HT receptor agonists on the expression of BDNF in brain was determined.
Administration of a hallucinogenic 5-HT 2A /2C receptor agonist, but not a 5-HT 1A receptor …

This brief review traces the serotonin (5-HT) hypothesis of the action of hallucinogenic
drugs from the early 1950s to the present day. There is now converging evidence from …

Previously, serotonin (5-HT) was found to induce a marked increase in glutamatergic spontaneous
excitatory postsynaptic currents (EPSCs) in apical dendrites of layer V pyramidal cells …

In prefrontal cortex, 5-hydroxytryptamine 2A (5-HT 2A ) receptors have been linked to the
action of hallucinogens and atypical antidepressant/antipsychotic drugs. Previously, we have …

Recently, the addition of drugs with prominent 5-HT 2 receptor antagonist properties (risperidone,
olanzapine, mirtazapine, and mianserin) to selective serotonin reuptake inhibitors (…

We compared 5-hydroxytryptamine (5-HT), norepinephrine and dopamine for their efficacy
at increasing excitatory postsynaptic current frequency in layer V pyramidal cells from rat …

Recent electrophysiological studies in our laboratory have demonstrated a physiological
interaction between 5-HT 2A and metabotropic glutamate2/3 (mGlu2/3) receptors in the medial …

Correlations between 5-hydroxytryptamine (5-HT) receptor binding affinities and human
hallucinogenic potency have suggested that 5-HT2 receptors mediate the hallucinogenic effects …

Dopamine D2 receptor blockade has been an obligate mechanism of action present in all
medications that effectively treat positive symptoms of schizophrenia (eg, delusions and …