A diet rich in salt is linked to an increased risk of cerebrovascular diseases and dementia, but
it remains unclear how dietary salt harms the brain. We report that, in mice, excess dietary …

Commensal gut bacteria impact the host immune system and can influence disease
processes in several organs, including the brain. However, it remains unclear whether the …

Hypertension is a leading risk factor for dementia, but the mechanisms underlying its damaging
effects on the brain are poorly understood. Due to a lack of energy reserves, the brain …

Dietary habits and vascular risk factors promote both Alzheimer’s disease and cognitive
impairment caused by vascular factors 1 , 2 – 3 . Furthermore, accumulation of …

The brain is highly dependent on an adequate delivery of oxygen and glucose from the
circulation, and cerebral blood flow (CBF) reductions impair neuronal function and, if protracted, …

Pharmacological manipulation of gene expression is considered a promising avenue to
reduce postischemic brain damage. Histone deacetylases (HDACs) play a central role in …

The NAD rescue pathway consists of two enzymatic steps operated by nicotinamide
phosphoribosyltransferase (Nampt) and nicotinamide mononucleotide adenylyltransferases. …

Perivascular macrophages (PVM) are a distinct population of resident brain macrophages
characterized by a close association with the cerebral vasculature. PVM migrate from the yolk …

The vasculature of the central nervous system (CNS) forms a selective barrier termed the
blood–brain barrier (BBB). Disruption of the BBB may contribute to various CNS diseases. …

Hypertension (HTN), a disease afflicting over one billion individuals worldwide, is a leading
cause of cognitive impairment, the mechanisms of which remain poorly understood. In the …