Extracellular matrix and perineuronal nets in CNS repair

JCF Kwok, G Dick, D Wang… - Developmental …, 2011 - Wiley Online Library
A perineuronal net (PNN) is a layer of lattice‐like matrix which enwraps the surface of the
soma and dendrites, and in some cases the axon initial segments, in sub‐populations of …

Removal of perineuronal nets unlocks juvenile plasticity through network mechanisms of decreased inhibition and increased gamma activity

KK Lensjø, ME Lepperød, G Dick… - Journal of …, 2017 - Soc Neuroscience
Perineuronal nets (PNNs) are extracellular matrix structures mainly enwrapping
parvalbumin-expressing inhibitory neurons. The assembly of PNNs coincides with the end of the …

Aggrecan directs extracellular matrix-mediated neuronal plasticity

…, T Hafting, M Fyhn, JW Fawcett, G Dick - Journal of …, 2018 - Soc Neuroscience
In the adult brain, the extracellular matrix (ECM) influences recovery after injury, susceptibility
to mental disorders, and is in general a strong regulator of neuronal plasticity. The …

[HTML][HTML] Semaphorin 3A binds to the perineuronal nets via chondroitin sulfate type E motifs in rodent brains

G Dick, CL Tan, JN Alves, EME Ehlert, GM Miller… - Journal of Biological …, 2013 - ASBMB
Chondroitin sulfate (CS) and the CS-rich extracellular matrix structures called perineuronal
nets (PNNs) restrict plasticity and regeneration in the CNS. Plasticity is enhanced by …

The chemorepulsive axon guidance protein semaphorin3A is a constituent of perineuronal nets in the adult rodent brain

T Vo, D Carulli, EME Ehlert, JCF Kwok, G Dick… - Molecular and Cellular …, 2013 - Elsevier
In the adult rodent brain, subsets of neurons are surrounded by densely organised
extracellular matrix called perineuronal nets (PNNs). PNNs consist of hyaluronan, tenascin-R, …

Rab11 and its effector Rab coupling protein contribute to the trafficking of β1 integrins during axon growth in adult dorsal root ganglion neurons and PC12 cells

R Eva, E Dassie, PT Caswell, G Dick… - Journal of …, 2010 - Soc Neuroscience
Integrins play an important part in axon growth, but integrin traffic in neurons is poorly
understood. Expression of the tenascin-C-binding integrin α9 promotes axon regeneration. We …

Proteoglycan synthesis and Golgi organization in polarized epithelial cells

G Dick, LK Akslen-Hoel, F Grøndahl… - … of Histochemistry & …, 2012 - journals.sagepub.com
A large number of complex glycosylation mechanisms take place in the Golgi apparatus. In
epithelial cells, glycosylated protein molecules are transported to both the apical and the …

[HTML][HTML] A proteoglycan undergoes different modifications en route to the apical and basolateral surfaces of Madin-Darby canine kidney cells

H Tveit, G Dick, V Skibeli, K Prydz - Journal of biological chemistry, 2005 - ASBMB
We have grown polarized epithelial Madin-Darby canine kidney II (MDCK II) cells on filters
in the presence of [ 35 S]sulfate, [ 3 H]glucosamine, or [ 35 S]cysteine/[ 35 S]methionine to …

Overexpression of the 3′-phosphoadenosine 5′-phosphosulfate (PAPS) transporter 1 increases sulfation of chondroitin sulfate in the apical pathway of MDCK II …

G Dick, F Grøndahl, K Prydz - Glycobiology, 2008 - academic.oup.com
The canine 3′-phosphoadenosine 5′-phosphosulfate (PAPS) transporter 1 fused to GFP
was stably expressed with a typical Golgi localization in MDCK II cells (MDCK II-PAPST1). …

How many ways through the Golgi maze?

K Prydz, G Dick, H Tveit - Traffic, 2008 - Wiley Online Library
The secretory route in eukaryotic cells has been regarded as one common pathway from the
endoplasmic reticulum (ER) through the Golgi cisternae to the trans Golgi network where …