… In fact, the main product in the intermediate lobe is not -END-(1-31), but rather N-acetyl- -END-(1-27),
a peptide totally devoid of activity at the opioid receptor (Akil et alI981c). Similar …

There is a wide body of evidence to suggest the existence of at least three distinct opioid
receptor types in the CNS, referred to as~, 6, and K. This paper reviews some of the findings …

This article aims to review the literature concerning the choice of selectivity for hydrogels
based on classification, application and processing. Super porous hydrogels (SPHs) and …

Most psychiatric disorders are moderately to highly heritable. The degree to which genetic
variation is unique to individual disorders or shared across disorders is unclear. To examine …

Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide
association study (GWAS) including 20,352 cases and 31,358 controls of European descent, …

Rare coding variation has historically provided the most direct connections between gene
function and disease pathogenesis. By meta-analysing the whole exomes of 24,248 …

While there is an abundance of pharmacological and biochemical evidence to suggest the
existence of multiple opioid receptors, their precise localization within the brain is unclear. To …

The pattern and time course of brain activation in response to acute swim and restraint stress
were examined in the rat by in situ hybridization using complementary RNA probes specific …

Genome-wide expression profiling is a powerful tool for implicating novel gene ensembles
in cellular mechanisms of health and disease. The most popular platform for genome-wide …

Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting
substantial pleiotropy of contributing loci. However, the nature and mechanisms of these …