Spinocerebellar ataxia 7 (SCA7) is a neurodegenerative disease caused by a polyglutamine
(polyQ) expansion in the ataxin 7 (ATXN7) protein, a member of a multiprotein complex …

Background During their life, multicellular organisms are challenged with oxidative stress. It
is generated by several reactive oxygen species (ROS), may limit lifespan and has been …

The steroid hormone ecdysone influences Drosophila lifespan. Longevity is extended in
mutants deficient for ecdysone synthesis or mutants of the ecdysone receptor (EcR). However, …

Background During the last two decades progress in the genetics of aging in invertebrate
models such as C. elegans and D. melanogaster has clearly demonstrated the existence of …

THE segmented pattern of the Drosophila embryo depends on a regulatory cascade
involving three main classes of genes 1 . An early regulatory programme, set up before …

Septic injury triggers a rapid and widespread response in Drosophila adults that involves the
up‐regulation of many genes required to combat infection and for wound healing. Genome‐…

Ubiquitin proteases remove ubiquitin monomers or polymers to modify the stability or activity
of proteins and thereby serve as key regulators of signal transduction. Here, we describe …

Aging’s most obvious characteristic is the time dependent increase of an individual’s
probability to die. This lifelong process is accompanied by a large number of molecular and …

10.7554/eLife.43326.001 Glia are important modulators of neural activity, yet few studies link
glia to sleep regulation. We find that blocking activity of the endocytosis protein, dynamin, in …

Amyloid-β protein precursor (AβPP) and the microtubule-associated protein tau (MAPT) are
the two key players involved in Alzheimer's disease (AD) and are associated with amyloid …