User profiles for Hai Yan
Hai YanFormer Distinguished Professor of Neurooncology at Duke Verified email at duke.edu Cited by 38998 |
[HTML][HTML] IDH1 and IDH2 Mutations in Gliomas
Background A recent genomewide mutational analysis of glioblastomas (World Health
Organization [WHO] grade IV glioma) revealed somatic mutations of the isocitrate dehydrogenase …
Organization [WHO] grade IV glioma) revealed somatic mutations of the isocitrate dehydrogenase …
TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal
…, N Papadopoulos, H Yan - Proceedings of the …, 2013 - National Acad Sciences
Malignant cells, like all actively growing cells, must maintain their telomeres, but genetic
mechanisms responsible for telomere maintenance in tumors have only recently been …
mechanisms responsible for telomere maintenance in tumors have only recently been …
Isocitrate dehydrogenase 1 and 2 mutations in cancer: alterations at a crossroads of cellular metabolism
ZJ Reitman, H Yan - Journal of the National Cancer Institute, 2010 - academic.oup.com
Dysregulation of metabolism is a common phenomenon in cancer cells. The NADP + -dependent
isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2) function at a crossroads of cellular …
isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2) function at a crossroads of cellular …
The implications of IDH mutations for cancer development and therapy
CJ Pirozzi, H Yan - Nature Reviews Clinical Oncology, 2021 - nature.com
Mutations in the genes encoding the cytoplasmic and mitochondrial forms of isocitrate
dehydrogenase (IDH1 and IDH2, respectively; collectively referred to as IDH) are frequently …
dehydrogenase (IDH1 and IDH2, respectively; collectively referred to as IDH) are frequently …
Thermal comfort and building energy consumption implications–a review
L Yang, H Yan, JC Lam - Applied energy, 2014 - Elsevier
Buildings account for about 40% of the global energy consumption and contribute over 30%
of the CO 2 emissions. A large proportion of this energy is used for thermal comfort in …
of the CO 2 emissions. A large proportion of this energy is used for thermal comfort in …
An integrated genomic analysis of human glioblastoma multiforme
Glioblastoma multiforme (GBM) is the most common and lethal type of brain cancer. To identify
the genetic alterations in GBMs, we sequenced 20,661 protein coding genes, determined …
the genetic alterations in GBMs, we sequenced 20,661 protein coding genes, determined …
High Frequency of Mutations of the PIK3CA Gene in Human Cancers
Phosphatidylinositol 3-kinases (PI3Ks) are lipid kinases that regulate signaling pathways
important for neoplasia, including cell proliferation, adhesion, survival, and motility (1–3). To …
important for neoplasia, including cell proliferation, adhesion, survival, and motility (1–3). To …
Transforming single DNA molecules into fluorescent magnetic particles for detection and enumeration of genetic variations
D Dressman, H Yan, G Traverso… - Proceedings of the …, 2003 - National Acad Sciences
Many areas of biomedical research depend on the analysis of uncommon variations in
individual genes or transcripts. Here we describe a method that can quantify such variation at a …
individual genes or transcripts. Here we describe a method that can quantify such variation at a …
Altered Telomeres in Tumors with ATRX and DAXX Mutations
…, R McLendon, BA Rasheed, Y He, H Yan… - Science, 2011 - science.org
The proteins encoded by ATRX and DAXX participate in chromatin remodeling at telomeres
and other genomic sites. Because inactivating mutations of these genes are common in …
and other genomic sites. Because inactivating mutations of these genes are common in …
DBR: Depth-based routing for underwater sensor networks
Providing scalable and efficient routing services in underwater sensor networks (UWSNs) is
very challenging due to the unique characteristics of UWSNs. Firstly, UWSNs often employ …
very challenging due to the unique characteristics of UWSNs. Firstly, UWSNs often employ …