User profiles for Hai Yan

Hai Yan

Former Distinguished Professor of Neurooncology at Duke
Verified email at duke.edu
Cited by 38998

[HTML][HTML] IDH1 and IDH2 Mutations in Gliomas

H Yan, DW Parsons, G Jin, R McLendon… - New England journal …, 2009 - Mass Medical Soc
Background A recent genomewide mutational analysis of glioblastomas (World Health
Organization [WHO] grade IV glioma) revealed somatic mutations of the isocitrate dehydrogenase …

TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal

…, N Papadopoulos, H Yan - Proceedings of the …, 2013 - National Acad Sciences
Malignant cells, like all actively growing cells, must maintain their telomeres, but genetic
mechanisms responsible for telomere maintenance in tumors have only recently been …

Isocitrate dehydrogenase 1 and 2 mutations in cancer: alterations at a crossroads of cellular metabolism

ZJ Reitman, H Yan - Journal of the National Cancer Institute, 2010 - academic.oup.com
Dysregulation of metabolism is a common phenomenon in cancer cells. The NADP + -dependent
isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2) function at a crossroads of cellular …

The implications of IDH mutations for cancer development and therapy

CJ Pirozzi, H Yan - Nature Reviews Clinical Oncology, 2021 - nature.com
Mutations in the genes encoding the cytoplasmic and mitochondrial forms of isocitrate
dehydrogenase (IDH1 and IDH2, respectively; collectively referred to as IDH) are frequently …

Thermal comfort and building energy consumption implications–a review

L Yang, H Yan, JC Lam - Applied energy, 2014 - Elsevier
Buildings account for about 40% of the global energy consumption and contribute over 30%
of the CO 2 emissions. A large proportion of this energy is used for thermal comfort in …

An integrated genomic analysis of human glioblastoma multiforme

…, RL Strausberg, SKN Marie, SMO Shinjo, H Yan… - science, 2008 - science.org
Glioblastoma multiforme (GBM) is the most common and lethal type of brain cancer. To identify
the genetic alterations in GBMs, we sequenced 20,661 protein coding genes, determined …

High Frequency of Mutations of the PIK3CA Gene in Human Cancers

…, Z Wang, A Bardelli, N Silliman, J Ptak, S Szabo, H Yan… - Science, 2004 - science.org
Phosphatidylinositol 3-kinases (PI3Ks) are lipid kinases that regulate signaling pathways
important for neoplasia, including cell proliferation, adhesion, survival, and motility (1–3). To …

Transforming single DNA molecules into fluorescent magnetic particles for detection and enumeration of genetic variations

D Dressman, H Yan, G Traverso… - Proceedings of the …, 2003 - National Acad Sciences
Many areas of biomedical research depend on the analysis of uncommon variations in
individual genes or transcripts. Here we describe a method that can quantify such variation at a …

Altered Telomeres in Tumors with ATRX and DAXX Mutations

…, R McLendon, BA Rasheed, Y He, H Yan… - Science, 2011 - science.org
The proteins encoded by ATRX and DAXX participate in chromatin remodeling at telomeres
and other genomic sites. Because inactivating mutations of these genes are common in …

DBR: Depth-based routing for underwater sensor networks

H Yan, ZJ Shi, JH Cui - NETWORKING 2008 Ad Hoc and Sensor …, 2008 - Springer
Providing scalable and efficient routing services in underwater sensor networks (UWSNs) is
very challenging due to the unique characteristics of UWSNs. Firstly, UWSNs often employ …