[HTML][HTML] Intermittent hypoxia attenuates ischemia/reperfusion induced apoptosis in cardiac myocytes via regulating Bcl-2/Bax expression

JW Dong, HF Zhu, WZ Zhu, HL Ding, TM Ma, ZN Zhou - Cell research, 2003 - nature.com
Intermittent hypoxia has been shown to provide myocardial protection against ishemia/reperfusion-induced
injury. Cardiac myocyte loss through apoptosis has been reported in …

Brain-derived neurotrophic factor in the mesolimbic reward circuitry mediates nociception in chronic neuropathic pain

…, MJ Liu, H Liu, S Zhang, XY Guo, JX Yang, HL Ding… - Biological …, 2017 - Elsevier
Background The mesolimbic reward system plays a critical role in modulating nociception;
however, its underlying molecular, cellular, and neural circuitry mechanisms remain unknown…

Disinhibition of mesolimbic dopamine circuit by the lateral hypothalamus regulates pain sensation

…, T Fang, JX Yang, L Song, H Liu, HL Ding… - Journal of …, 2023 - Soc Neuroscience
Our recent study demonstrated the critical role of the mesolimbic dopamine (DA) circuit and
its brain-derived neurotropic factor (BDNF) signaling in mediating neuropathic pain. The …

Caveolin-1 in the anterior cingulate cortex modulates chronic neuropathic pain via regulation of NMDA receptor 2B subunit

…, LY Hao, L Yu, P Wu, CJ Shao, HL Ding… - Journal of …, 2015 - Soc Neuroscience
Chronic pain is still a basic science and clinical challenge. Unraveling of the neurobiological
mechanisms involved in chronic pain will offer novel targets for the development of …

Hydroxymethylation of microRNA-365-3p regulates nociceptive behaviors via Kcnh2

…, GF Li, LY Hao, LJ Zhu, YQ Li, HL Ding… - Journal of …, 2016 - Soc Neuroscience
DNA 5-hydroxylmethylcytosine (5hmC) catalyzed by ten-eleven translocation methylcytosine
dioxygenase (TET) occurs abundantly in neurons of mammals. However, the in vivo causal …

Inducible nitric oxide synthase contributes to intermittent hypoxia against ischemia/reperfusion injury

H Ding, H Zhu, J Dong, W Zhu, W Yang… - Acta Pharmacologica …, 2005 - nature.com
Aim: To investigate the role of inducible nitric oxide synthase (iNOS)-derived nitric oxide (NO)
in the cardioprotection of intermittent hypoxia (IH) against ischemia/reperfusion (I/R) injury. …

GABAergic neurons in the dorsal–intermediate lateral septum regulate sleep–wakefulness and anesthesia in mice

…, XX Kong, YM Yu, JX Yang, H Zhang, HL Ding… - …, 2021 - pubs.asahq.org
Background The γ-aminobutyric acid–mediated (GABAergic) inhibitory system in the brain
is critical for regulation of sleep–wake and general anesthesia. The lateral septum contains …

Brain-derived neurotrophic factor–mediated projection-specific regulation of depressive-like and nociceptive behaviors in the mesolimbic reward circuitry

…, H Liu, YM Zhang, SY Wu, Y Song, B Juarez, HL Ding… - Pain, 2018 - journals.lww.com
Increasing evidence suggests that the mesolimbic reward system plays critical roles in the
regulation of depression and nociception; however, its circuitry and cellular mechanisms …

Activation of the spinal ERK signaling pathway contributes naloxone-precipitated withdrawal in morphine-dependent rats

JL Cao, JH He, HL Ding, YM Zeng - Pain, 2005 - Elsevier
Extracellular signal-regulated kinase (ERK), a mitogen-activated protein kinases (MAPK),
transduces a broad range of extracellular stimuli into diverse intracellular responses. Recent …

Contralateral projection of anterior cingulate cortex contributes to mirror-image pain

…, WN Zhao, QZ Li, JX Yang, S An, HL Ding… - Journal of …, 2021 - Soc Neuroscience
Long-term limb nerve injury often leads to mirror-image pain (MIP), an abnormal pain sensation
in the limb contralateral to the injury. Although it is clear that MIP is mediated in part by …