[PDF][PDF] Toward a neurocentric view of learning

HK Titley, N Brunel, C Hansel - Neuron, 2017 - cell.com
Synaptic plasticity (eg, long-term potentiation [LTP]) is considered the cellular correlate of
learning. Recent optogenetic studies on memory engram formation assign a critical role in …

[HTML][HTML] Cerebellar plasticity and motor learning deficits in a copy-number variation mouse model of autism

…, HK Titley, H Nakayama, K Hashimoto… - Nature …, 2014 - nature.com
A common feature of autism spectrum disorder (ASD) is the impairment of motor control and
learning, occurring in a majority of children with autism, consistent with perturbation in …

This was my Crimean War: COVID-19 experiences of nursing home leaders

A Savage, S Young, HK Titley, TE Thorne… - Journal of the American …, 2022 - Elsevier
Objective To describe professional and personal experiences of nursing home care leaders
during early waves of the COVID-19 pandemic. Design Qualitative interpretive description. …

[HTML][HTML] SK2 channels in cerebellar Purkinje cells contribute to excitability modulation in motor-learning–specific memory traces

G Grasselli, HJ Boele, HK Titley, N Bradford… - PLoS …, 2020 - journals.plos.org
Neurons store information by changing synaptic input weights. In addition, they can adjust
their membrane excitability to alter spike output. Here, we demonstrate a role of such “intrinsic …

Behavioral tests for mouse models of autism: an argument for the inclusion of cerebellum-controlled motor behaviors

DH Simmons, HK Titley, C Hansel, P Mason - Neuroscience, 2021 - Elsevier
Mouse models of Autism Spectrum Disorder (ASD) have been interrogated using a variety
of behavioral tests in order to understand the symptoms of ASD. However, the hallmark …

Cracks in the foundation: The experience of care aides in long‐term care homes during the COVID‐19 pandemic

HK Titley, S Young, A Savage, T Thorne… - Journal of the …, 2023 - Wiley Online Library
… pandemic - Titley - 2023 - Journal of the American Geriatrics Society - Wiley Online Library
Heather K Titley led manuscript preparation. All authors contributed substantially to drafting …

Intrinsic excitability increase in cerebellar Purkinje cells after delay eye-blink conditioning in mice

HK Titley, GV Watkins, C Lin, C Weiss… - Journal of …, 2020 - Soc Neuroscience
Cerebellar-based learning is thought to rely on synaptic plasticity, particularly at synaptic
inputs to Purkinje cells. Recently, however, other complementary mechanisms have been …

Calcium threshold shift enables frequency-independent control of plasticity by an instructive signal

C Piochon, HK Titley, DH Simmons… - Proceedings of the …, 2016 - National Acad Sciences
At glutamatergic synapses, both long-term potentiation (LTP) and long-term depression (LTD)
can be induced at the same synaptic activation frequency. Instructive signals determine …

Motor learning in the VOR: the cerebellar component

DM Broussard, HK Titley, J Antflick… - Experimental brain …, 2011 - Springer
This paper reviews results that support a model in which memory for VOR gain is initially
encoded in the flocculus, and in which cerebellar LTD and LTP are responsible for gain …

Complex spike clusters and false‐positive rejection in a cerebellar supervised learning rule

HK Titley, M Kislin, DH Simmons… - The Journal of …, 2019 - Wiley Online Library
… The concentration of 5 mm [K + ] o that was selected in the present study therefore reflects
K + concentrations that are typical for the ionic milieu during activity, which the aCSF should …