User profiles for Holden D. Brown

Holden D Brown

Postdoctoral Fellow, Stanford University
Verified email at stanford.edu
Cited by 985

Primary food reward and reward‐predictive stimuli evoke different patterns of phasic dopamine signaling throughout the striatum

HD Brown, JE McCutcheon, JJ Cone… - European journal of …, 2011 - Wiley Online Library
Phasic changes in dopamine activity play a critical role in learning and goal‐directed behavior.
Unpredicted reward and reward‐predictive cues evoke phasic increases in the firing rate …

[HTML][HTML] Prostaglandin signaling suppresses beneficial microglial function in Alzheimer's disease models

…, X Liang, A Trueba-Saiz, HD Brown… - The Journal of …, 2015 - Am Soc Clin Investig
Microglia, the innate immune cells of the CNS, perform critical inflammatory and noninflammatory
functions that maintain normal neural function. For example, microglia clear misfolded …

The parafascicular thalamic nucleus concomitantly influences behavioral flexibility and dorsomedial striatal acetylcholine output in rats

HD Brown, PM Baker, ME Ragozzino - Journal of Neuroscience, 2010 - Soc Neuroscience
Recent evidence suggests that a circuit involving the centromedian–parafascicular (Pf) thalamus
and basal ganglia is critical for a shift away from biased actions. In particular, excitatory …

Suppression of inflammation with conditional deletion of the prostaglandin E2 EP2 receptor in macrophages and brain microglia

…, NS Woodling, N Ko, HD Brown… - Journal of …, 2013 - Soc Neuroscience
Prostaglandin E 2 (PGE 2 ), a potent lipid signaling molecule, modulates inflammatory
responses through activation of downstream G-protein coupled EP 1–4 receptors. Here, we …

The selective serotonin reuptake inhibitor, escitalopram, enhances inhibition of prepotent responding and spatial reversal learning

HD Brown, DA Amodeo, JA Sweeney… - Journal of …, 2012 - journals.sagepub.com
Previous findings indicate treatment with a selective serotonin reuptake inhibitor (SSRI)
facilitates behavioral flexibility when conditions require inhibition of a learned response pattern. …

[HTML][HTML] Meticillin-resistant Staphylococcus aureus with a novel mecA homologue in human and bovine populations in the UK and Denmark: a descriptive study

L García-Álvarez, MTG Holden, H Lindsay… - The Lancet infectious …, 2011 - thelancet.com
Background Animals can act as a reservoir and source for the emergence of novel meticillin-resistant
Staphylococcus aureus (MRSA) clones in human beings. Here, we report the …

Study of slip mechanisms in a magnesium alloy by neutron diffraction and modeling

SR Agnew, CN Tomé, DW Brown, TM Holden… - Scripta materialia, 2003 - Elsevier
Internal strains within a polycrystalline magnesium alloy plate have been measured during
tensile and compression testing in situ by neutron diffraction. Using an elasto-plastic self-…

Internal strain and texture evolution during deformation twinning in magnesium

DW Brown, SR Agnew, MAM Bourke, TM Holden… - Materials Science and …, 2005 - Elsevier
… , δ d 0 h k l ,(2) δ ε = ε δ d h k l d h k l + δ d 0 h k l d 0 h k l Again due to the initial texture,
the diffracted intensity of the (0 0 0 2) peak in the Q || detector is initially absent. Based on the …

Deeply-scaled self-aligned-gate GaN DH-HEMTs with ultrahigh cutoff frequency

…, D Regan, A Corrion, D Brown… - 2011 International …, 2011 - ieeexplore.ieee.org
We report record DC and RF performance in deeply-scaled self-aligned gate (SAG) GaN-HEMTs
operating in both depletion-mode (D-mode) and enhancement-mode (E-mode). …

Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease

…, EY Chen, S Palfi, BZ Roitberg, WD Brown, JE Holden… - Science, 2000 - science.org
Lentiviral delivery of glial cell line–derived neurotrophic factor (lenti-GDNF) was tested for
its trophic effects upon degenerating nigrostriatal neurons in nonhuman primate models of …