User profiles for Holden D. Brown
Holden D BrownPostdoctoral Fellow, Stanford University Verified email at stanford.edu Cited by 985 |
Primary food reward and reward‐predictive stimuli evoke different patterns of phasic dopamine signaling throughout the striatum
Phasic changes in dopamine activity play a critical role in learning and goal‐directed behavior.
Unpredicted reward and reward‐predictive cues evoke phasic increases in the firing rate …
Unpredicted reward and reward‐predictive cues evoke phasic increases in the firing rate …
[HTML][HTML] Prostaglandin signaling suppresses beneficial microglial function in Alzheimer's disease models
…, X Liang, A Trueba-Saiz, HD Brown… - The Journal of …, 2015 - Am Soc Clin Investig
Microglia, the innate immune cells of the CNS, perform critical inflammatory and noninflammatory
functions that maintain normal neural function. For example, microglia clear misfolded …
functions that maintain normal neural function. For example, microglia clear misfolded …
The parafascicular thalamic nucleus concomitantly influences behavioral flexibility and dorsomedial striatal acetylcholine output in rats
Recent evidence suggests that a circuit involving the centromedian–parafascicular (Pf) thalamus
and basal ganglia is critical for a shift away from biased actions. In particular, excitatory …
and basal ganglia is critical for a shift away from biased actions. In particular, excitatory …
Suppression of inflammation with conditional deletion of the prostaglandin E2 EP2 receptor in macrophages and brain microglia
…, NS Woodling, N Ko, HD Brown… - Journal of …, 2013 - Soc Neuroscience
Prostaglandin E 2 (PGE 2 ), a potent lipid signaling molecule, modulates inflammatory
responses through activation of downstream G-protein coupled EP 1–4 receptors. Here, we …
responses through activation of downstream G-protein coupled EP 1–4 receptors. Here, we …
The selective serotonin reuptake inhibitor, escitalopram, enhances inhibition of prepotent responding and spatial reversal learning
Previous findings indicate treatment with a selective serotonin reuptake inhibitor (SSRI)
facilitates behavioral flexibility when conditions require inhibition of a learned response pattern. …
facilitates behavioral flexibility when conditions require inhibition of a learned response pattern. …
[HTML][HTML] Meticillin-resistant Staphylococcus aureus with a novel mecA homologue in human and bovine populations in the UK and Denmark: a descriptive study
L García-Álvarez, MTG Holden, H Lindsay… - The Lancet infectious …, 2011 - thelancet.com
Background Animals can act as a reservoir and source for the emergence of novel meticillin-resistant
Staphylococcus aureus (MRSA) clones in human beings. Here, we report the …
Staphylococcus aureus (MRSA) clones in human beings. Here, we report the …
Study of slip mechanisms in a magnesium alloy by neutron diffraction and modeling
Internal strains within a polycrystalline magnesium alloy plate have been measured during
tensile and compression testing in situ by neutron diffraction. Using an elasto-plastic self-…
tensile and compression testing in situ by neutron diffraction. Using an elasto-plastic self-…
Internal strain and texture evolution during deformation twinning in magnesium
… , δ d 0 h k l ,(2) δ ε = ε δ d h k l d h k l + δ d 0 h k l d 0 h k l Again due to the initial texture,
the diffracted intensity of the (0 0 0 2) peak in the Q || detector is initially absent. Based on the …
the diffracted intensity of the (0 0 0 2) peak in the Q || detector is initially absent. Based on the …
Deeply-scaled self-aligned-gate GaN DH-HEMTs with ultrahigh cutoff frequency
…, D Regan, A Corrion, D Brown… - 2011 International …, 2011 - ieeexplore.ieee.org
We report record DC and RF performance in deeply-scaled self-aligned gate (SAG) GaN-HEMTs
operating in both depletion-mode (D-mode) and enhancement-mode (E-mode). …
operating in both depletion-mode (D-mode) and enhancement-mode (E-mode). …
Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease
…, EY Chen, S Palfi, BZ Roitberg, WD Brown, JE Holden… - Science, 2000 - science.org
Lentiviral delivery of glial cell line–derived neurotrophic factor (lenti-GDNF) was tested for
its trophic effects upon degenerating nigrostriatal neurons in nonhuman primate models of …
its trophic effects upon degenerating nigrostriatal neurons in nonhuman primate models of …