The RAS-mitogen-activated protein kinase (MAPK) signaling pathway plays critical roles in
brain function, including learning and memory. Mutations of molecules in the RAS-MAPK …

In Noonan syndrome (NS) 30–50% of subjects show cognitive deficits of unknown etiology
and with no known treatment. Here, we report that knock-in mice expressing either of two NS-…

… Author links open overlay panel Hyun-Hee Ryu a b 1 , Mi-Hee Jun a 1 , Kyung-Jin Min a , …
Hyun-Hee Ryu, Mi-Hee Jun, Kyung-Jin Min and Jin-A Lee performed most of the experiments. …

Neurite growth requires neurite extension and retraction, which are associated with protein
degradation. Autophagy is a conserved bulk degradation pathway that regulates several …

Control of Ca 2+ flux between the cytosol and intracellular Ca 2+ stores is essential for
maintaining normal cellular function. It has been well established in both neuronal and non-…

Although many reports have revealed dysfunction of endothelial cells in aging, resulting in
blood-brain barrier (BBB) breakdown, the underlying mechanism or mechanisms remain to …

Autism spectrum disorders (ASDs) are a group of developmental disorders that cause variable
and heterogeneous phenotypes across three behavioral domains such as atypical social …

CD38 is an enzyme that catalyzes the formation of cyclic ADP ribose and nicotinic acid
adenine dinucleotide phosphate, both of which are involved in the mobilization of Ca 2+ from …

Multiple brain regions are engaged in classical fear conditioning. Despite evidence for
cerebellar involvement in fear conditioning, the mechanisms by which cerebellar outputs …

Mutations in RAS signaling pathway components cause diverse neurodevelopmental disorders,
collectively called RASopathies. Previous studies have suggested that dysregulation in …