[HTML][HTML] Transcriptional repression of PGC-1α by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration
L Cui, H Jeong, F Borovecki, CN Parkhurst, N Tanese… - Cell, 2006 - cell.com
Huntington's disease (HD) is an inherited neurodegenerative disease caused by a glutamine
repeat expansion in huntingtin protein. Transcriptional deregulation and altered energy …
repeat expansion in huntingtin protein. Transcriptional deregulation and altered energy …
Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease
AW Dunah, H Jeong, A Griffin, YM Kim, DG Standaert… - Science, 2002 - science.org
Huntington's disease (HD) is an inherited neurodegenerative disease caused by expansion
of a polyglutamine tract in the huntingtin protein. Transcriptional dysregulation has been …
of a polyglutamine tract in the huntingtin protein. Transcriptional dysregulation has been …
[HTML][HTML] Acetylation targets mutant huntingtin to autophagosomes for degradation
H Jeong, F Then, TJ Melia, JR Mazzulli, L Cui… - Cell, 2009 - cell.com
Huntington's disease (HD) is an incurable neurodegenerative disease caused by neuronal
accumulation of the mutant protein huntingtin. Improving clearance of the mutant protein is …
accumulation of the mutant protein huntingtin. Improving clearance of the mutant protein is …
Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway
H Jeong, DE Cohen, L Cui, A Supinski, JN Savas… - Nature medicine, 2012 - nature.com
Sirt1, a NAD-dependent protein deacetylase, has emerged as a key regulator of mammalian
transcription in response to cellular metabolic status and stress 1 . Here we show that Sirt1 …
transcription in response to cellular metabolic status and stress 1 . Here we show that Sirt1 …
Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets
M Jiang, J Wang, J Fu, L Du, H Jeong, T West… - Nature medicine, 2012 - nature.com
Huntington's disease is a fatal neurodegenerative disorder caused by an expanded
polyglutamine repeat in huntingtin (HTT) protein. We previously showed that calorie restriction …
polyglutamine repeat in huntingtin (HTT) protein. We previously showed that calorie restriction …
[HTML][HTML] In vitro analysis of huntingtin-mediated transcriptional repression reveals multiple transcription factor targets
W Zhai, H Jeong, L Cui, D Krainc, R Tjian - Cell, 2005 - cell.com
Transcriptional dysregulation has emerged as a potentially important pathogenic mechanism
in Huntington's disease, a neurodegenerative disorder associated with polyglutamine …
in Huntington's disease, a neurodegenerative disorder associated with polyglutamine …
Indocyanine green encapsulated nanogels for hyaluronidase activatable and selective near infrared imaging of tumors and lymph nodes
H Mok, H Jeong, SJ Kim, BH Chung - Chemical communications, 2012 - pubs.rsc.org
Indocyanine green (ICG) encapsulated hyaluronic acid (HA) nanogels were first studied for
highly selective detection of specific cancers and lymph nodes via hyaluronidase sensitive …
highly selective detection of specific cancers and lymph nodes via hyaluronidase sensitive …
Mutant huntingtin is secreted via a late endosomal/lysosomal unconventional secretory pathway
K Trajkovic, H Jeong, D Krainc - Journal of Neuroscience, 2017 - Soc Neuroscience
Huntington9s disease (HD) is an autosomal-dominant neurodegenerative disorder caused
by the expansion of a CAG triplet in the gene encoding for huntingtin (Htt). The resulting …
by the expansion of a CAG triplet in the gene encoding for huntingtin (Htt). The resulting …
Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein
…, M de Haro, AK Wagner Gee, SA Titus, H Jeong… - elife, 2017 - elifesciences.org
10.7554/eLife.29123.001 The discovery of the causative gene for Huntington’s disease (HD)
has promoted numerous efforts to uncover cellular pathways that lower levels of mutant …
has promoted numerous efforts to uncover cellular pathways that lower levels of mutant …
Lysosomal ceramides regulate cathepsin B-mediated processing of saposin C and glucocerebrosidase activity
MJ Kim, H Jeong, D Krainc - Human molecular genetics, 2022 - academic.oup.com
Variants in multiple lysosomal enzymes increase Parkinson’s disease (PD) risk, including
the genes encoding glucocerebrosidase (GCase), acid sphingomyelinase (ASMase) and …
the genes encoding glucocerebrosidase (GCase), acid sphingomyelinase (ASMase) and …