… -9 also induces synaptic remodeling in hippocampal neuron cultures, and an MMP-9
inhibitor, minocycline, enhances dendritic spine and synapse stability in vitro and in vivo (Ethell …

Dendritic spines are small protrusions that cover the surface of dendrites and bear the
postsynaptic component of excitatory synapses. Having an enlarged head connected to the …

The extracellular matrix (ECM) is a critical regulator of neural network development and
plasticity. As neuronal circuits develop, the ECM stabilizes synaptic contacts, while its cleavage …

The Ca 2+ -activated protein phosphatase calcineurin induces apoptosis, but the mechanism
is unknown. Calcineurin was found to dephosphorylate BAD, a pro-apoptotic member of …

… DW Ethell, … IM Ethell … We thank Dr Michael Tranfaglia and members of the Ethell
laboratories for helpful discussions and Hani El Shawa for technical help. …

Here, using a genetic approach, we dissect the roles of EphB receptor tyrosine kinases in
dendritic spine development. Analysis of EphB1, EphB2, and EphB3 double and triple mutant …

We previously reported that the cell surface proteoglycan syndecan-2 can induce dendritic
spine formation in hippocampal neurons. We demonstrate here that the EphB2 receptor …

Background Fragile X syndrome (FXS) is a disorder characterized by a variety of disabilities,
including cognitive deficits, attention-deficit/hyperactivity disorder, autism, and other socio-…

Dendritic spines are small protrusions that receive synapses, and changes in spine morphology
are thought to be the structural basis for learning and memory. We demonstrate that the …

The function of the multi-PDZ domain scaffold protein GRIP1 (glutamate receptor interacting
protein 1) in neurons is unclear. To explore the function of GRIP1 in hippocampal neurons, …