Checkpoint inhibitors have revolutionized cancer treatment. However, only a minority of
patients respond to these immunotherapies. Here, we report that blocking the inhibitory NKG2A …

Congenital hyperinsulinism (HI) is an inappropriate insulin secretion by the pancreatic β-cells
secondary to various genetic disorders. The incidence is estimated at 1/50, 000 live births, …

Microglial cells are the resident macrophages of the central nervous system (CNS) and are
mainly known for their roles in neuropathologies. However, major recent developments have …

Microparticles (MPs) resulting from vesiculation of platelets and other blood cells have been
extensively documented in vitro and have been found in increased numbers in several …

Type-I edge-localized modes (ELMs) have been mitigated at the JET tokamak using a static
external n= 1 perturbation field generated by four error field correction coils located far from …

The response of drosophila to bacterial and fungal infections involves two signaling pathways,
Toll and Imd, which both activate members of the transcription factor NF-κB family. Here …

The fruit fly Drosophila melanogaster is a model system for studying innate immunity, including
antiviral host defense. Infection with drosophila C virus triggers a transcriptional response …

The development of vasculopathies in diabetes involves multifactorial processes including
pathological activation of vascular cells. Release of microparticles by activated cells has been …

Accumulative evidence indicates that microglial cells influence the normal development of
brain synapses. Yet, the mechanisms by which these immune cells target maturating …

Drosophila, like other invertebrates and plants, relies mainly on RNA interference for its
defense against viruses. In flies, viral infection also triggers the expression of many genes. One …