New anti‐actin drugs in the study of the organization and function of the actin cytoskeleton
I Spector, F Braet, NR Shochet… - … research and technique, 1999 - Wiley Online Library
The high degree of structural and molecular complexity of the actin‐based cytoskeleton,
combined with its ability to reorganize rapidly and locally in response to stimuli, and its force‐…
combined with its ability to reorganize rapidly and locally in response to stimuli, and its force‐…
Inhibition of actin polymerization by latrunculin A
M Coué, SL Brenner, I Spector, ED Korn - FEBS letters, 1987 - Elsevier
Latrunculin A, a toxin purified from the red sea sponge Latrunculia magnifica, was found
previously to induce striking reversible changes in the morphology of mammalian cells in …
previously to induce striking reversible changes in the morphology of mammalian cells in …
Latrunculins: novel marine toxins that disrupt microfilament organization in cultured cells
I Spector, NR Shochet, Y Kashman, A Groweiss - Science, 1983 - science.org
Two toxins, latrunculins A and B, which contain a new class of 16- and 14-membered marine
macrolides attached to the rare 2-thiazolidinone moiety, were purified recently from the Red …
macrolides attached to the rare 2-thiazolidinone moiety, were purified recently from the Red …
Latrunculins—novel marine macrolides that disrupt microfilament organization and affect cell growth: I. Comparison with cytochalasin D
I Spector, NR Shochet, D Blasberger… - Cell motility and the …, 1989 - Wiley Online Library
The latrunculins are architecturally novel marine compounds isolated from the Red Sea
sponge Latrunculia magnifica. In vivo, they alter cell shape, disrupt microfilament organization, …
sponge Latrunculia magnifica. In vivo, they alter cell shape, disrupt microfilament organization, …
Role of actin in anchoring postsynaptic receptors in cultured hippocampal neurons: differential attachment of NMDA versus AMPA receptors
DW Allison, VI Gelfand, I Spector… - Journal of …, 1998 - Soc Neuroscience
We used actin-perturbing agents and detergent extraction of primary hippocampal cultures
to test directly the role of the actin cytoskeleton in localizing GABA A receptors, AMPA- and …
to test directly the role of the actin cytoskeleton in localizing GABA A receptors, AMPA- and …
[HTML][HTML] Effects of jasplakinolide on the kinetics of actin polymerization: an explanation for certain in vivo observations
MR Bubb, I Spector, BB Beyer, KM Fosen - Journal of Biological Chemistry, 2000 - ASBMB
Jasplakinolide paradoxically stabilizes actin filaments in vitro, but in vivo it can disrupt actin
filaments and induce polymerization of monomeric actin into amorphous masses. A detailed …
filaments and induce polymerization of monomeric actin into amorphous masses. A detailed …
[HTML][HTML] Actin-latrunculin A structure and function: differential modulation of actin-binding protein function by latrunculin A
…, T Somasundaram, TA Boring, I Spector… - Journal of Biological …, 2000 - ASBMB
Latrunculin A is used extensively as an agent to sequester monomeric actin in living cells.
We hypothesize that additional activities of latrunculin A may be important for its biological …
We hypothesize that additional activities of latrunculin A may be important for its biological …
[HTML][HTML] Swinholide A Is a Microfilament Disrupting Marine Toxin That Stabilizes Actin Dimers and Severs Actin Filaments (∗)
MR Bubb, I Spector, AD Bershadsky, ED Korn - Journal of Biological …, 1995 - ASBMB
Swinholide A, isolated from the marine sponge Theonella swinhoei, is a 44-carbon ring
dimeric dilactone macrolide with a 2-fold axis of symmetry. Recent studies have elucidated its …
dimeric dilactone macrolide with a 2-fold axis of symmetry. Recent studies have elucidated its …
Diatom gliding is the result of an actin‐myosin motility system
NC Poulsen, I Spector, TP Spurck… - Cell motility and the …, 1999 - Wiley Online Library
Diatoms are a group of unicellular microalgae that are encased in a highly ornamented
siliceous cell wall, or frustule. Pennate diatoms have bilateral symmetry and many genera …
siliceous cell wall, or frustule. Pennate diatoms have bilateral symmetry and many genera …
Latrunculin-A increases outflow facility in the monkey.
…, T Volberg, RE Gangnon, I Spector… - … & visual science, 1999 - iovs.arvojournals.org
PURPOSE: To determine the effect of Latrunculin (LAT)-A, a macrolide that binds to G-actin,
which leads to the disassembly of actin filaments, on shape, junctions, and the cytoskeleton …
which leads to the disassembly of actin filaments, on shape, junctions, and the cytoskeleton …