User profiles for Inês S. Amorim
Inês S. AmorimUniversity of Edinbugh Verified email at exseed.ed.ac.uk Cited by 331 |
Autistic-like behavior and cerebellar dysfunction in Bmal1 mutant mice ameliorated by mTORC1 inhibition
Although circadian and sleep disorders are frequently associated with autism spectrum
disorders (ASD), it remains elusive whether clock gene disruption can lead to autistic-like …
disorders (ASD), it remains elusive whether clock gene disruption can lead to autistic-like …
[HTML][HTML] The role of the eukaryotic translation initiation factor 4E (eIF4E) in neuropsychiatric disorders
Protein synthesis in eukaryotic cells is a complex, multi-step and tightly regulated process.
Translation initiation, the rate limiting step in protein synthesis, is dependent on the activity of …
Translation initiation, the rate limiting step in protein synthesis, is dependent on the activity of …
Loss of eIF4E phosphorylation engenders depression-like behaviors via selective mRNA translation
The MAPK/ERK (mitogen-activated protein kinases/extracellular signal-regulated kinase)
pathway is a cardinal regulator of synaptic plasticity, learning, and memory in the hippocampus…
pathway is a cardinal regulator of synaptic plasticity, learning, and memory in the hippocampus…
[HTML][HTML] Translational profiling of dorsal root ganglia and spinal cord in a mouse model of neuropathic pain
Acute pain serves as a protective mechanism, guiding the organism away from actual or
potential tissue injury. In contrast, chronic pain is a debilitating condition without any obvious …
potential tissue injury. In contrast, chronic pain is a debilitating condition without any obvious …
Sideroflexin 3 is an α-synuclein-dependent mitochondrial protein that regulates synaptic morphology
IS Amorim, LC Graham, RN Carter… - Journal of Cell …, 2017 - journals.biologists.com
α-Synuclein plays a central role in Parkinson's disease, where it contributes to the vulnerability
of synapses to degeneration. However, the downstream mechanisms through which α-…
of synapses to degeneration. However, the downstream mechanisms through which α-…
Molecular neuropathology of the synapse in sheep with CLN 5 Batten disease
Aims Synapses represent a major pathological target across a broad range of neurodegenerative
conditions. Recent studies addressing molecular mechanisms regulating synaptic …
conditions. Recent studies addressing molecular mechanisms regulating synaptic …
Mnk1/2 kinases regulate memory and autism-related behaviours via Syngap1
…, E Statoulla, K Simbriger, IS Amorim, S Kouloulia… - Brain, 2023 - academic.oup.com
MAPK interacting protein kinases 1 and 2 (Mnk1/2) regulate a plethora of functions, presumably
via phosphorylation of their best characterized substrate, eukaryotic translation initiation …
via phosphorylation of their best characterized substrate, eukaryotic translation initiation …
[HTML][HTML] Uncovering memory-related gene expression in contextual fear conditioning using ribosome profiling
Contextual fear conditioning (CFC) in rodents is the most widely used behavioural paradigm
in neuroscience research to elucidate the neurobiological mechanisms underlying learning …
in neuroscience research to elucidate the neurobiological mechanisms underlying learning …
[PDF][PDF] eIF4E phosphorylation recruits β-catenin to mRNA cap and promotes Wnt pathway translation in dentate gyrus LTP maintenance
…, TF Mergiya, K Krimbacher, IS Amorim, S Akerkar… - Iscience, 2023 - cell.com
The mRNA cap-binding protein, eukaryotic initiation factor 4E (eIF4E), is crucial for translation
and regulated by Ser209 phosphorylation. However, the biochemical and physiological …
and regulated by Ser209 phosphorylation. However, the biochemical and physiological …
[PDF][PDF] Raptor-mediated proteasomal degradation of deamidated 4E-BP2 regulates postnatal neuronal translation and NF-κB activity
The translation initiation repressor 4E-BP2 is deamidated in the brain on asparagines N99/N102
during early postnatal brain development. This post-translational modification …
during early postnatal brain development. This post-translational modification …