User profiles for Irene Dalla Costa

Irene Dalla Costa

University of South Carolina
Verified email at email.sc.edu
Cited by 227

The functional organization of axonal mRNA transport and translation

I Dalla Costa, CN Buchanan, MD Zdradzinski… - Nature Reviews …, 2021 - nature.com
Axons extend for tremendously long distances from the neuronal soma and make use of
localized mRNA translation to rapidly respond to different extracellular stimuli and physiological …

Axonal precursor mi RNA s hitchhike on endosomes and locally regulate the development of neural circuits

E Corradi, I Dalla Costa, A Gavoci, A Iyer… - The EMBO …, 2020 - embopress.org
Various species of non‐coding RNA s (ncRNAs) are enriched in specific subcellular
compartments, but the mechanisms orchestrating their localization and their local functions remain …

Automatic segmentation of lung parenchyma in the presence of diseases based on curvature of ribs

…, MS Brown, S Ahmad, F Abtin, J Allen, I da Costa… - Academic radiology, 2008 - Elsevier
RATIONALE AND OBJECTIVES: Segmentation of lungs using high-resolution computer
tomographic images in the setting of diffuse lung diseases is a major challenge in medical …

Axon initial segments are required for efficient motor neuron axon regeneration and functional recovery of synapses

LH Teliska, I Dalla Costa, O Sert, JL Twiss… - Journal of …, 2022 - Soc Neuroscience
The axon initial segment (AIS) generates action potentials and maintains neuronal polarity
by regulating the differential trafficking and distribution of proteins, transport vesicles, and …

Reproducibility of lung and lobar volume measurements using computed tomography

MS Brown, HJ Kim, F Abtin, I Da Costa, R Pais… - Academic radiology, 2010 - Elsevier
RATIONALE AND OBJECTIVES: Lung and lobar volume measurements from computed
tomographic (CT) imaging are being used in clinical trials to assess new minimally invasive …

Emphysema lung lobe volume reduction: effects on the ipsilateral and contralateral lobes

…, M Galperin-Aizenberg, R Pais, IG Da Costa… - European …, 2012 - Springer
Objectives To investigate volumetric and density changes in the ipsilateral and contralateral
lobes following volume reduction of an emphysematous target lobe. Methods The study …

Integration of chest CT CAD into the clinical workflow and impact on radiologist efficiency

…, F Abtin, S Ghahremani, N Yaghmai, I da Costa… - Academic radiology, 2019 - Elsevier
Rationale and Objectives The purpose of this paper is to describe the integration of a commercial
chest CT computer-aided detection (CAD) system into the clinical radiology reporting …

[PDF][PDF] Teneurin trans-axonal signaling prunes topographically missorted axons

O Spead, T Moreland, CJ Weaver, I Dalla Costa… - Cell reports, 2023 - cell.com
Building precise neural circuits necessitates the elimination of axonal projections that have
inaccurately formed during development. Although axonal pruning is a selective process, …

Intra-axonal translation of Khsrp mRNA slows axon regeneration by destabilizing localized mRNAs

…, M Dell'Orco, DE Cassidy, ID Costa… - Nucleic acids …, 2022 - academic.oup.com
Axonally synthesized proteins support nerve regeneration through retrograde signaling and
local growth mechanisms. RNA binding proteins (RBP) are needed for this and other …

CAD in clinical trials: current role and architectural requirements

…, R Pais, SK Shah, P Qing, I Da Costa… - … Medical Imaging and …, 2007 - Elsevier
Computer-aided diagnosis (CAD) technology is becoming an important tool to assess treatment
response in clinical trials. However, CAD software alone is not sufficient to conduct an …