Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization

AR Pombo Antunes, I Scheyltjens, F Lodi… - Nature …, 2021 - nature.com
Glioblastomas are aggressive primary brain cancers that recur as therapy-resistant tumors.
Myeloid cells control glioblastoma malignancy, but their dynamics during disease …

A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment

H Van Hove, L Martens, I Scheyltjens… - Nature …, 2019 - nature.com
While the roles of parenchymal microglia in brain homeostasis and disease are fairly clear,
other brain-resident myeloid cells remain less well understood. By dissecting border regions …

Differential plasticity and fate of brain-resident and recruited macrophages during the onset and resolution of neuroinflammation

K De Vlaminck, H Van Hove, D Kancheva, I Scheyltjens… - Immunity, 2022 - cell.com
Microglia and border-associated macrophages (BAMs) are brain-resident self-renewing
cells. Here, we examined the fate of microglia, BAMs, and recruited macrophages upon …

[HTML][HTML] Understanding the glioblastoma immune microenvironment as basis for the development of new immunotherapeutic strategies

AR Pombo Antunes, I Scheyltjens, J Duerinck, B Neyns… - Elife, 2020 - elifesciences.org
Cancer immunotherapy by immune checkpoint blockade has proven its great potential by
saving the lives of a proportion of late stage patients with immunogenic tumor types. However, …

[PDF][PDF] A binary Cre transgenic approach dissects microglia and CNS border-associated macrophages

JS Kim, M Kolesnikov, S Peled-Hajaj, I Scheyltjens… - Immunity, 2021 - cell.com
The developmental and molecular heterogeneity of tissue macrophages is unravelling, as
are their diverse contributions to physiology and pathophysiology. Moreover, also given …

[PDF][PDF] Interleukin-10 prevents pathological microglia hyperactivation following peripheral endotoxin challenge

A Shemer, I Scheyltjens, GR Frumer, JS Kim… - Immunity, 2020 - cell.com
Microglia, the resident macrophages of the brain parenchyma, are key players in central
nervous system (CNS) development, homeostasis, and disorders. Distinct brain pathologies …

[HTML][HTML] Therapeutic depletion of CCR8+ tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy

…, B Neyns, S Ocak, I Scheyltjens… - … for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Background Modulation and depletion strategies of regulatory T cells (Tregs) constitute valid
approaches in antitumor immunotherapy but suffer from severe adverse effects due to their …

Single-cell RNA and protein profiling of immune cells from the mouse brain and its border tissues

I Scheyltjens, H Van Hove, K De Vlaminck… - Nature …, 2022 - nature.com
Brain–immune cross-talk and neuroinflammation critically shape brain physiology in health
and disease. A detailed understanding of the brain immune landscape is essential for …

[HTML][HTML] CSF1R inhibition rescues tau pathology and neurodegeneration in an A/T/N model with combined AD pathologies, while preserving plaque associated …

C Lodder, I Scheyltjens, IC Stancu… - Acta neuropathologica …, 2021 - Springer
Alzheimer's disease (AD) is characterized by a sequential progression of amyloid plaques (A),
neurofibrillary tangles (T) and neurodegeneration (N), constituting ATN pathology. While …

Identifying the variables that drive tamoxifen‐independent CreERT2 recombination: implications for microglial fate mapping and gene deletions

…, K De Vlaminck, I Scheyltjens… - European journal of …, 2020 - Wiley Online Library
Ligand‐dependent Cre recombinases such as the CreERT2 system allow for tamoxifen‐inducible
Cre recombination. Important examples are the Cx3cr1‐CreERT2 and Sall1‐CreERT2 …